Chengfu Xu

First Affiliated Hospital Zhejiang University

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Chaohui Yu

First Affiliated Hospital Zhejiang University

Youming Li

Zhejiang University

Han Ma

Zhejiang University

Min Miao

Ningbo University

Youming Li

First Affiliated Hospital Zhejiang University

Lei Xu

Zhejiang University

Xingyong Wan

Zhejiang University

Jinghua Wang

First Affiliated Hospital Zhejiang University

Shenghui Chen

First Affiliated Hospital Zhejiang University

Zhe Shen

First Affiliated Hospital Zhejiang University

Cooperative Institutions

American Gastroenterological Association

113

Zhejiang University

106

First Affiliated Hospital Zhejiang University

Cairo University

Peking University

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

University Gastroenterology

Sun Yat-sen University

Weatherford College

Shanghai Jiao Tong University

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Mo1543 Inhibition of MPST Prevents Hepatic Steatosis Through Hydrogen Sulfide-Dependent Mechanism

Gastroenterology (2016)

Meng Li Chengfu Xu Xingyong Wan Jianguo Gao Chaohui Yu

Steatosis

10.1016/s0016-5085(16)33847-1

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Citations (0)

High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver Disease: A Prospective Observational Study

PLoS ONE (2010)

Chengfu Xu Chaohui Yu Lei Xu Min Miao Youming Li

Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients. However, whether this elevation is causal, a bystander, or a consequence of NAFLD remains unclear. We performed a population-based prospective study among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China to investigate whether the elevation of serum uric acid has a casual role for NAFLD. A total of 6890 initially NAFLD-free subjects were followed up for 3 years. Overall, 11.80% (813/6890) subjects developed NAFLD over 3 years of follow-up. The cumulative incidence of NAFLD increased with progressively higher baseline serum uric acid levels (the cumulative incidence was 7.2%, 9.5%, 11.5%, 13.8%, and 17.2% in quintile 1, quintile 2, 3, 4 and 5, respectively; P value for trend <0.001). Cox proportional hazards regression analyses showed that serum uric acid levels were independently and positively associated with the risk for incident NAFLD; the age-, gender- and metabolic syndrome adjusted hazard ratio (95% CI) for the subjects in quintile 2, 3, 4 and 5 versus quintile 1 was 1.18 (0.91-1.54), 1.32 (1.03-1.70), 1.39 (1.09-1.78) and 1.50 (1.18-1.92), respectively. Taken together, our prospective observational study showed that elevation of serum uric acid levels independently predicts increase risk for incident NAFLD.

Cumulative incidence

10.1371/journal.pone.0011578

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Citations (150)

Inhibiting Hepatocyte Uric Acid Synthesis and Reabsorption Ameliorates Acetaminophen-Induced Acute Liver Injury in Mice

Cellular and Molecular Gastroenterology and Hepatology (2023)

Chenxi Tang Li Cen Hang Zeng Xiaofen Zhang Peihao Liu

Acetaminophen (APAP) overdose is the most common cause of drug-induced liver injury worldwide. Uric acid (UA) is involved in sterile inflammation in many organs, but its role in APAP-induced liver injury remains elusive.

Acetaminophen

10.1016/j.jcmgh.2023.10.005

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Citations (4)

Colo-colonic intussusception as a rare complication of colonoscopy with polypectomy: Two case reports

World Journal of Gastrointestinal Surgery (2024)

Sai-Heng Xiang Chengfu Xu

BACKGROUND Colonoscopy is the most frequently used diagnostic and therapeutic tool for the treatment of colorectal diseases. Although the complication rate is low, it can be potentially serious. Intussusception is a rare and severe complication often associated with polypectomy. Only a handful of post-colonoscopy intussusception cases have been reported, making this study a valuable addition to the medical literature. CASE SUMMARY Case 1: A 61-year-old man underwent colonoscopy with polypectomy for chronic abdominal pain. The patient experienced abdominal pain 11 hours later but was still discharged after pain management. He was readmitted due to recurring pain. Computed tomography (CT) showed colo-colonic intussusception. Initial conservative management and attempts at endoscopic reduction failed; therefore, laparoscopic right hemicolectomy was performed. Histopathological examination revealed tubular adenomas in the polyps and inflammation in the resected specimens. Case 2: A 59-year-old woman underwent colonoscopy with polypectomy for a polyp in the transverse colon. She experienced upper abdominal pain, fever, nausea, and vomiting 9 hours after the procedure. Emergency CT and blood tests revealed a colo-colonic intussusception near the hepatic flexure and an elevated white blood cell count. Initial attempts at endoscopic reduction failed and conservative treatment showed no improvement. She underwent successful laparoscopic reduction and recovered uneventfully. Histopathological examination of the resected polyp revealed hyperplasia. CONCLUSION Post-colonoscopy intussusception in adults is rare, and polypectomy may contribute to its occurrence. Early diagnosis is crucial, with prompt CT examination serving as key. After excluding malignancies, conservative management and reduction of intussusception should be considered before surgical bowel resection.

Polypectomy

Transverse colon

10.4240/wjgs.v16.i6.1939

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Citations (1)

Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn's Disease and Intestinal Tuberculosis

PLoS ONE (2016)

Fenming Zhang Chengfu Xu Longgui Ning Fengling Hu Guodong Shan

Aim To explore the diagnostic models of Crohn's disease (CD), Intestinal tuberculosis (ITB) and the differential diagnostic model between CD and ITB by analyzing serum proteome profiles. Methods Serum proteome profiles from 30 CD patients, 21 ITB patients and 30 healthy controls (HCs) were analyzed by using weak cationic magnetic beads combined with MALDI-TOF-MS technique to detect the differentially expressed proteins of serum samples. Three groups were made and compared accordingly: group of CD patients and HCs, group of ITB patients and HCs, group of CD patients and ITB patients. Wilcoxon rank sum test was used to screen the ten most differentiated protein peaks (P < 0.05). Genetic algorithm combining with support vector machine (SVM) was utilized to establish the optimal diagnostic models for CD, ITB and the optimal differential diagnostic model between CD and ITB. The predictive effects of these models were evaluated by Leave one out (LOO) cross validation method. Results There were 236 protein peaks differently expressed between group of CD patients and HCs, 305 protein peaks differently expressed between group of ITB patients and HCs, 332 protein peaks differently expressed between group of CD patients and ITB patients. Ten most differentially expressed peaks were screened out between three groups respectively (P < 0.05) to establish diagnostic models and differential diagnostic model. A diagnostic model comprising of four protein peaks (M/Z 4964, 3029, 2833, 2900) can well distinguish CD patients and HCs, with a specificity and sensitivity of 96.7% and 96.7% respectively. A diagnostic model comprising four protein peaks (M/Z 3030, 2105, 2545, 4210) can well distinguish ITB patients and HCs, with a specificity and sensitivity of 93.3% and 95.2% respectively. A differential diagnostic model comprising three potential biomarkers protein peaks (M/Z 4267, 4223, 1541) can well distinguish CD patients and ITB patients, with a specificity and sensitivity of 76.2% and 80.0% respectively. Among the eleven protein peaks from the diagnostic models and differential diagnostic model, two have been successfully purified and identified, Those two peaks were M/Z 2900 from the diagnostic model between CD and HCs and M/Z 1541 from the differential diagnostic model between CD and ITB. M/Z 2900 was identified as appetite peptide, M/Z 1541 was identified as Lysyl oxidase-like 2 (LOXL-2). Conclusion The differently expressed protein peaks analyzed by serum proteome with weak cationic magnetic beads combined MALDI-TOF-MS technique can effectively distinguish CD patients and HCs, ITB patients and HCs, CD patients and ITB patients. The diagnostic model between CD patients and HCs consisting of four protein peaks (M/Z 4964, 3029, 2833, 2900), the diagnostic model between ITB patients and HCs comprising four protein peaks (M/Z 3030, 2105, 2545, 4210) and the differential diagnostic model between CD patients and ITB patients comprising three protein peaks (M/Z 4267, 4223, 1541) had high specificity and sensitivity and can contribute to diagnoses of CD, ITB and the differential diagnosis between CD and ITB. Two proteins from the diagnostic model of CD and the differential diagnostic model between CD and ITB were identified. Further experiments are required using a larger cohort of samples.

INTESTINAL TUBERCULOSIS

Profiling (computer programming)

Crohn disease

10.1371/journal.pone.0167109

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Citations (25)

Olfactomedin-4 in digestive diseases: A mini-review

World Journal of Gastroenterology (2018)

Xinyu Wang Shenghui Chen Yanan Zhang Chengfu Xu

Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family.The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow.Previous studies have revealed that OLFM4 is closely associated with many digestive diseases.Up-regulation of OLFM4 has been detected in the Helicobacter pylori (H.pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer.Downregulation of OLFM4 has also been detected in some cases, such as in poorly differentiated, advancedstage and metastatic tumors.Studies using OLFM4deficient mouse models have revealed that OLFM4 acts as a negative regulator of H. pylori -specific immune responses and plays an important role in mucosal defense in inflammatory bowel disease.Patients with OLFM4-positive gastric cancer or colorectal cancer have a better survival rate than OLFM4-negative patients.However, the prognosis is worse in pancreatic cancer patients with high levels of expression of OLFM4.The NF-κB, Notch and Wnt signaling pathways are involved in the regulation of OLFM4 expression in digestive diseases, and its role in pathogenesis is associated with anti-inflammation, apoptosis, cell adhesion and proliferation.OLFM4 may serve as a potential specific diagnostic marker and a therapeutic target in digestive diseases.Further studies are required to explore the clinical value of OLFM4.

10.3748/wjg.v24.i17.1881

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Citations (46)

T1864 Early Mortality of Alcoholic Hepatitis: A Review of Data from Placebo-Controlled Clinical Trials

Gastroenterology (2009)

Youming Li Chaohui Yu Yue Wang Chengfu Xu

Alcoholic Hepatitis

10.1016/s0016-5085(09)63932-9

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Citations (1)

Endoscopic polypectomy: A promising therapeutic choice for esophageal carcinosarcoma

World Journal of Gastroenterology (2009)

Feng Ji Yuemei Xu Chengfu Xu

Esophageal carcinosarcoma is a rare malignant tumor composing of both carcinomatous and sarcomatous elements.Endoscopic therapy is less invasive and may represent an alternative to esophagectomy for superficial esophageal carcinosarcoma.Here, we report a 61-year-old male who was diagnosed as esophageal carcinosarcoma and underwent endoscopic polypectomy with well tolerance and favorable prognosis.We also present a brief review of the literature.

Carcinosarcoma

Esophagectomy

Polypectomy

10.3748/wjg.15.3448

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Citations (14)

Correction: Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn’s Disease and Intestinal Tuberculosis

PLoS ONE (2019)

Fenming Zhang Chengfu Xu Longgui Ning Fengling Hu Guodong Shan

[This corrects the article DOI: 10.1371/journal.pone.0167109.].

INTESTINAL TUBERCULOSIS

Crohn disease

10.1371/journal.pone.0212300

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Citations (2)

Decreased Levels of Active SMAD2 Correlate with Poor Prognosis in Gastric Cancer

PLoS ONE (2012)

Yijun Wu Qi Li Xinhui Zhou Jiren Yu Yunchuan Mu

TGF-β plays a dual role in the progression of human cancer. During the early stages of carcinogenesis, TGF-β functions as a tumor suppressor. During the late stages of tumor development, however, TGF-β can promote tumor growth and metastasis. A shift in Smad2/3 phosphorylation from the carboxy terminus to linker sites is a key event determining biological function of TGF-β in colorectal and hepatocellular carcinoma. In the present study, we investigated the potential role of differential Smad2/3 phosphorylation in gastric adenocarcinoma.Immunohistochemical staining with anti-P-Smad2/3C and P-Smad2/3L antibodies was performed on 130 paraffin-embedded gastric adenocarcinoma specimens. The relationship between P-Smad2/3C and P-Smad2/3L immunohistochemical score and clinicopathologic characteristics of patients was analyzed. Real time PCR was used to measure mRNA expression of Smad2 and Smad3 in cancer and surrounding non-tumor tissue.No significant P-Smad2L and/or P-Smad3L positive staining was detected in the majority of specimens (positive staining in 18/130 samples). Positive P-Smad2/3L staining was not associated with a decrease in carboxyterminal phosphorylation staining. Loss of P-Smad2C remarkably correlated with depth of tumor infiltration and poor differentiation of cancer cells in patients with gastric cancer. No correlation was detectable between P-Smad3C and clinicopathologic characteristics of gastric adenocarcinoma. However, co-staining analysis revealed that P-Smad3C co-localised with α-SMA and collagen I in gastric cancer cells, indicating a potential link between P-Smad3C and epithelial-to-mesenchymal transition of cancer. Real time PCR demonstrated reduced mRNA expression of Smad2 in gastric cancer when compared with surrounding non-tumor tissue in 15/16 patients.Loss of P-Smad2C tightly correlated with cancer invasion and poor differentiation in gastric cancer. Contrary to colorectal and hepatocellular carcinoma, canonical carboxy-terminal phosphorylation, but not linker phosphorylation, of Smad2 is critical for gastric cancer.

Tumor progression

10.1371/journal.pone.0035684

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Citations (25)