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    Equilibrium fractionation
    Mass-independent fractionation
    Cassiterite
    Pegmatite
    Isotope Geochemistry
    Equilibrium fractionation
    Mass-independent fractionation
    Isotopes of sulfur
    Minerals and rocks exhibit various isotope compositions depending on their origins and histories. In interpreting their isotopic variations, the equilibrium isotope fractionation factor is a key because it depends on the environment parameters such as temperature. Recent studies have shown that the effect of pressure on the isotope fractionation, which was considered negligible compared to temperature, is significant under the conditions of the Earth's interior. In this article we review recent advances in experimental studies to determine the isotope fractionation of iron and hydrogen at high pressure over several GPa, discussing their issues and future perspectives.
    Equilibrium fractionation
    Mass-independent fractionation
    Hydrogen isotope
    Kinetic isotope effect
    Isotope Geochemistry
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