CikA, a Bacteriophytochrome That Resets the Cyanobacterial Circadian Clock
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Abstract:
The circadian oscillator of the cyanobacterium Synechococcus elongatus , like those in eukaryotes, is entrained by environmental cues. Inactivation of the gene cikA (circadian input kinase) shortens the circadian period of gene expression rhythms in S . elongatus by approximately 2 hours, changes the phasing of a subset of rhythms, and nearly abolishes resetting of phase by a pulse of darkness. The CikA protein sequence reveals that it is a divergent bacteriophytochrome with characteristic histidine protein kinase motifs and a cryptic response regulator motif. CikA is likely a key component of a pathway that provides environmental input to the circadian oscillator in S . elongatus .Keywords:
Histidine kinase
Oscillating gene
Darkness
Biological clock