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    The Efficacy of Rebamipide on Endoscopical, Histopathological Severity and Free Radicals in Chronic Gastritis
    The American Journal of Gastroenterology (2010)
    Marcellus SimadibrataAri Fahrial SyamAbdul Aziz RaniSeptelia Inawati WanandiMurdani Abdullah
    Purpose: Free radicals have a role in the development of chronic gastritis. The aim of this study to know the effect and efficacy of Rebamipide on free radicals in chronic gastritis. Methods: Forty one patients in the Division of Gastroenterology, Dr Cipto Mangunkusumo Hospital Jakarta 2009-2010 with moderate and severe gastritis endoscopically were included in this study. Before and after Rebamipide treatment the patient were performed endoscopical examination and were taken 5 biopsies for histopathological examination and free radicals (MDA & Carbonyl Compound) examination. All patients were given Rebamipide 3 x 100 mg/day for 28 days. Data were analyzed with paired t test. Exclusion: GERD, Peptic ulcer, PPI treatment, NSAID consumption. Results: The most frequent characteristic was male (51.2%), age 42.44+/11.72 years old. The mean+/SD score of mucosal damage on day 0 was 2.268+/0.448 vs. day 28 was 1.707+/0.782 (p<0.001). The mean+/SD antrum neutrophil: day 0: 0.122+/0.458 vs. day 28: 0.097+/0.375 and mean+/SD corpus neutrophil: day 0: 0.122+/0.399 vs. day 28: 0.073+/0.264. Rebamipide can reduce the mean level of MDA from 5.617 +/ 3.544 nmol/mg protein on day 0 to 4.498 +/ 2.709 nmol/mg protein on day 28 (p=0.047). The mean of carbonyl compound on day 0 was 4.949 +/ 3.009 umol/mg protein and on day 28 was 5.201 +/ 2.828 umol/mg protein (p=0.642). Conclusion: Rebamipide can reduce the mucosal damage and the MDA level in chronic gastritis. This research was supported by an industry grant from PT. Otsuka Indonesia.
    Rebamipide
    Chronic gastritis
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