Ying Zhang

Jining Medical University

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Yuanji Xu

University of Science and Technology Beijing

Shun Yao

University of Nottingham Ningbo China

Teresa Sánchez

Cornell University

Hannah Le

Pfizer (United States)

Tong Shangguan

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Patrick A. Ott

Dana-Farber Cancer Institute

T. Kim Le

Bryn Mawr College

Linlin Zhang

Chinese Academy of Sciences

Junfeng Su

Xi'an University of Architecture and Technology

Miqi Ren

Xi'an University of Architecture and Technology

Cooperative Institutions

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Sun Yat-sen University

Central South University

Jilin University

Sun Yat-sen University Cancer Center

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

University of Science and Technology Beijing

Tsinghua University

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Construction of Z-scheme InN/BTe heterostructure for enhanced photocatalytic hydrogen evolution: DFT calculation and mechanism study

International Journal of Hydrogen Energy (2024)

Can Li Hao Liang Zhiqiang Xu Tao Ji Ying Zhang

Photocatalytic water splitting

10.1016/j.ijhydene.2024.04.228

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Citations (7)

A nomogram incorporating linezolid and metabolite concentrations for predicting linezolid induced thrombocytopenia in patients with renal impairment

Scientific Reports (2024)

Hanzhen Zhao Lian Tang Zhiwei Zhuang Ying Zhang Jingjing Li

Nomogram

Linezolid

10.1038/s41598-024-77768-x

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Citations (0)

Simultaneous removal of nitrate, manganese, zinc, and bisphenol A by a biofilm reactor with β-CD modified corn stover biochar and PU sponges: Performance and microbial community response

Environmental Research (2024)

Miqi Ren Junfeng Su Yihan Bai Yue Wang Chenxi Hou

Stover

Corn stover

10.1016/j.envres.2024.120156

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Citations (2)

Enhanced passivation of lead and cadmium from contaminated farmland using biochar with tailored pore properties: Performance and mechanisms

Chemical Engineering Journal (2024)

Yue Tao Shuqi Wei Yang Xu Lu Han Fuxuan Bi

Passivation

10.1016/j.cej.2024.154467

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Citations (1)

Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α

Scientific Reports (2019)

Liangzhong Zhao Ziyu Liu Fang Yang Ying Zhang Ying Xue

Abstract Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor that regulates the expression of target genes involved in angiogenesis. Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1α to promote its degradation. This study was designed to construct an intrabody against PHD2 that can inhibit PHD2 activity and promote angiogenesis. Single-chain variable fragment (scFv) against PHD2, INP, was isolated by phage display technique and was modified with an endoplasmic reticulum (ER) sequence to obtain ER-retained intrabody against PHD2 (ER-INP). ER-INP was efficiently expressed and bound to PHD2 in cells, significantly increased the levels of HIF-1α, and decreased hydroxylated HIF-1α in human embryonic kidney cell line (HEK293) cells and mouse mononuclear macrophage leukaemia cell line (RAW264.7) cells. ER-INP has shown distinct angiogenic activity both in vitro and in vivo , as ER-INP expression significantly promoted the migration and tube formation of human umbilical vein endothelial cells (HUVECs) and enhanced angiogenesis of chick chorioallantoic membranes (CAMs). Furthermore, ER-INP promoted distinct expression and secretion of a range of angiogenic factors. To the best of our knowledge, this is the first study to report an ER-INP intrabody enhancing angiogenesis by blocking PHD2 activity to increase HIF-1α abundance and activity. These results indicate that ER-INP may play a role in the clinical treatment of tissue injury and ischemic diseases in the future.

Chorioallantoic membrane

Hypoxia-Inducible Factors

HEK 293 cells

10.1038/s41598-019-47891-1

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Citations (11)

The dual effects of Benzo(a)pyrene/Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide on DNA Methylation

The Science of The Total Environment (2024)

Cheng Zhao Huixin Jin Lei Yu Qilin Li Ying Zhang

10.1016/j.scitotenv.2024.175042

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Citations (0)

Electric-field control of skyrmions in multiferroic heterostructure via magnetoelectric coupling

Nature Communications (2021)

You Ba Shihao Zhuang Yike Zhang Yutong Wang Yang Gao

Abstract Room-temperature skyrmions in magnetic multilayers are considered to be promising candidates for the next-generation spintronic devices. Several approaches have been developed to control skyrmions, but they either cause significant heat dissipation or require ultrahigh electric fields near the breakdown threshold. Here, we demonstrate electric-field control of skyrmions through strain-mediated magnetoelectric coupling in ferromagnetic/ferroelectric multiferroic heterostructures. We show the process of non-volatile creation of multiple skyrmions, reversible deformation and annihilation of a single skyrmion by performing magnetic force microscopy with in situ electric fields. Strain-induced changes in perpendicular magnetic anisotropy and interfacial Dzyaloshinskii–Moriya interaction strength are characterized experimentally. These experimental results, together with micromagnetic simulations, demonstrate that strain-mediated magnetoelectric coupling (via strain-induced changes in both the perpendicular magnetic anisotropy and interfacial Dzyaloshinskii–Moriya interaction is responsible for the observed electric-field control of skyrmions. Our work provides a platform to investigate electric-field control of skyrmions in multiferroic heterostructures and paves the way towards more energy-efficient skyrmion-based spintronics.

Skyrmion

10.1038/s41467-020-20528-y

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Citations (113)

Field-free topological behavior in the magnetic domain wall of ferrimagnetic GdFeCo

Nature Communications (2021)

Zhuolin Li Jian Su Shi‐Zeng Lin Dan Liu Yang Gao

Abstract Exploring and controlling topological textures such as merons and skyrmions has attracted enormous interests from the perspective of fundamental research and spintronic applications. It has been predicted theoretically and proved experimentally that the lattice form of topological meron-skyrmion transformation can be realized with the requirement of external magnetic fields in chiral ferromagnets. However, such topological transition behavior has yet to be verified in other materials. Here, we report real-space observation of magnetic topology transformation between meron pairs and skyrmions in the localized domain wall of ferrimagnetic GdFeCo films without the need of magnetic fields. The topological transformation in the domain wall of ferrimagnet is introduced by temperature-induced spin reorientation transition (SRT) and the underlying mechanism is revealed by micromagnetic simulations. The convenient electric-controlling topology transformation and driving motion along the confined domain wall is further anticipated, which will enable advanced application in magnetic devices.

Ferrimagnetism

Skyrmion

Domain wall (magnetism)

10.1038/s41467-021-25926-4

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Citations (14)

The electrochemistry of stable sulfur isotopes versus lithium

Proceedings of the National Academy of Sciences (2024)

Xueting Li Yao Zhao Yuhui Zhu Wenpeng Wang Ying Zhang

Sulfur in nature consists of two abundant stable isotopes, with two more neutrons in the heavy one ( 34 S) than in the light one ( 32 S). The two isotopes show similar physicochemical properties and are usually considered an integral system for chemical research in various fields. In this work, a model study based on a Li–S battery was performed to reveal the variation between the electrochemical properties of the two S isotopes. Provided with the same octatomic ring structure, the cyclo - 34 S 8 molecules form stronger S–S bonds than cyclo - 32 S 8 and are more prone to react with Li. The soluble Li polysulfides generated by the Li– 34 S conversion reaction show a stronger cation–solvent interaction yet a weaker cation–anion interaction than the 32 S-based counterparts, which facilitates quick solvation of polysulfides yet hinders their migration from the cathode to the anode. Consequently, the Li– 34 S cell shows improved cathode reaction kinetics at the solid–liquid interface and inhibited shuttle of polysulfides through the electrolyte so that it demonstrates better cycling performance than the Li– 32 S cell. Based on the varied shuttle kinetics of the isotopic-S-based polysulfides, an electrochemical separation method for 34 S/ 32 S isotope is proposed, which enables a notably higher separation factor than the conventional separation methods via chemical exchange or distillation and brings opportunities to low-cost manufacture, utilization, and research of heavy chalcogen isotopes.

Isotopes of lithium

Kinetic isotope effect

10.1073/pnas.2316564121

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Citations (2)

A novel Dy4 cluster constructed by an 8‑hydroxyquinoline Schiff base showing remarkable single molecule magnet behavior

Polyhedron (2021)

Haitang Wang Jin-Rong Pu Xin Li Yue Zhang Ying Zhang

Dysprosium

Acetylacetone

Magnetic Relaxation

Single-molecule magnet

10.1016/j.poly.2021.115117

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Citations (3)