Paul F. Becker

Helmholtz Zentrum München

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Christoph A. Klein

Deutsches Herzzentrum der Charité

Kathrin Weidele

Fraunhofer Institute for Toxicology and Experimental Medicine

Sebastian Haferkamp

University Hospital Regensburg

Daniela Mihic‐Probst

University Hospital of Zurich

Alexander Hapfelmeier

Technical University of Munich

Andreas Trumpp

Heidelberg University

Dieter Saur

German Cancer Research Center

Corinna Klein

Heidelberg Institute for Stem Cell Technology and Experimental Medicine

Norbert Hüser

Technical University of Munich

Sebastian Lange

Technical University of Munich

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Technical University of Munich

Heidelberg University

German Cancer Research Center

Helmholtz Zentrum München

Klinikum rechts der Isar

DKFZ-ZMBH Alliance

München Klinik

Ludwig-Maximilians-Universität München

University Hospital of Zurich

University of Zurich

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Single cell polarity in liquid phase facilitates tumour metastasis

Nature Communications (2018)

Anna Lorentzen Paul F. Becker Jan Kosla Massimo Saini Kathrin Weidele

Abstract Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.

Cell polarity

Polarity (international relations)

10.1038/s41467-018-03139-6

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Citations (53)