Le Han

Vietnam National University Ho Chi Minh City

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Xiaoguang Wu

Nanjing Medical University

Abhijit Saha

CIC bioGUNE

Shinsuke Sato

Kyoto University

Thangavel Vaijayanthi

Kyoto University

Jing Pang

Chinese Academy of Medical Sciences & Peking Union Medical College

Shengyong Mao

Nanjing Agricultural University

Hong-Fei Zhang

China University of Geosciences

Qiang Zuo

Second People’s Hospital of Yibin

Bin Zhao

Tianjin Hospital

Shane Lloyd

Huntsman Cancer Institute

Cooperative Institutions

Kyoto University

Graduate School USA

Nanjing Agricultural University

China Agricultural University

Chinese Academy of Medical Sciences & Peking Union Medical College

Xi'an Jiaotong University

Shaanxi Provincial People's Hospital

Ministry of Agriculture and Rural Affairs

Ministry of Education of the People's Republic of China

Capital Medical University

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Determining threshold values for root-soil water weighted plant water deficit index based smart irrigation

Agricultural Water Management (2019)

Jianchu Shi Xun Wu Xiaoyu Wang Mo Zhang Le Han

Water Use Efficiency

Water use

10.1016/j.agwat.2019.105979

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Citations (23)

The efficacy-associated biomarkers for immune checkpoint inhibitors in gastrointestinal cancer: a literature review

Journal of Gastrointestinal Oncology (2024)

Peixi Zhao Rui Jin Bin Zhao Le Han Wenjuan Chen

Background and Objective: Immune checkpoint inhibitors (ICIs) have been widely applied and studied in the treatment of gastrointestinal (GI) cancers, and have achieved good results. However, in clinical practice, it has been observed that only some patients respond well to ICIs, and some patients may experience various degrees of adverse reactions during the treatment. Timely evaluation of the potential therapeutic effects and adverse reactions of ICIs for patients has important clinical significance. This review aimed to summarize recent progress regarding efficacy-associated biomarkers for ICIs in GI cancer. Methods: The literature on ICI treatment in GI cancers was searched in the PubMed, Embase, and Cochrane Library databases for publications up to April 2023. Key Content and Findings: Clinical practice and research has gradually revealed some biomarkers related to the treatment of GI cancers with ICIs, which can be roughly divided into three types: biomarkers that predict the effectiveness of ICIs treatment, biomarkers associated with resistance to ICIs, and biomarkers associated with immune related adverse events (irAEs). This review article provides a literature review on biomarkers related to the efficacy of ICIs in the treatment of GI cancers. Conclusions: According to existing clinical research results, there are multiple biomarkers that can be used for predicting and monitoring the efficacy and risk of adverse events of ICIs in the treatment of digestive system malignant tumors.

Clinical Practice

10.21037/jgo-23-843

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Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

Scientific Reports (2014)

Ganesh N. Pandian Junichi Taniguchi Junetha Syed Shinsuke Sato Le Han

The influential role of the epigenome in orchestrating genome-wide transcriptional activation instigates the demand for the artificial genetic switches with distinct DNA sequence recognition. Recently, we developed a novel class of epigenetically active small molecules called SAHA-PIPs by conjugating selective DNA binding pyrrole-imidazole polyamides (PIPs) with the histone deacetylase inhibitor SAHA. Screening studies revealed that certain SAHA-PIPs trigger targeted transcriptional activation of pluripotency and germ cell genes in mouse and human fibroblasts, respectively. Through microarray studies and functional analysis, here we demonstrate for the first time the remarkable ability of thirty-two different SAHA-PIPs to trigger the transcriptional activation of exclusive clusters of genes and noncoding RNAs. QRT-PCR validated the microarray data and some SAHA-PIPs activated therapeutically significant genes like KSR2. Based on the aforementioned results, we propose the potential use of SAHA-PIPs as reagents capable of targeted transcriptional activation.

Epigenome

10.1038/srep03843

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Long noncoding RNA expression profile changes associated with dietary energy in the sheep testis during sexual maturation

Scientific Reports (2017)

Yanli Zhang Hua Yang Le Han Fengzhe Li Tingting Zhang

Abstract Spermatogenesis can be affected by nutrition, which operates through normal physiological processes by changing the testicular mass and hormone levels profoundly. However, little is known regarding how testis development is regulated by long noncoding RNA (lncRNA). In this study, we investigated the effects of high-grain (HG) feeding on testis development during sexual maturation mediated by lncRNA. The HG diet group showed an increase in growth hormone (GH), insulin-like growth factor-1 (IGF-1) and testosterone (T) levels, and in the number of sperm in the seminiferous tubules compared with the hay-fed group ( p < 0.05). Moreover, we found 59 differentially expressed (DE) lncRNAs and 229 DE mRNAs in sheep testis between the two groups. qRT-PCR results of 20 randomly selected DE lncRNAs and mRNAs were also consistent with the RNA-seq data. Through functional enrichment analysis and lncRNA-mRNA interaction network analysis, we screened several lncRNAs that may be enriched for male reproduction such as spermatogenesis, sperm motility, steroid hormones, MAPK and ErbB signaling pathways. This study provides a first insight into the development of the testis with HG feeding in sheep and shows that these changes are associated with alterations in lncRNA expression.

10.1038/s41598-017-05443-5

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Citations (43)