Weiyong Li

Huazhong University of Science and Technology

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Jingxin Zhao

Lanzhou Jiaotong University

Jun He

University of Science and Technology of China

Fukun Chen

University of Science and Technology of China

Xiguang Huang

Chinese Academy of Sciences

Risheng Ye

University of Science and Technology of China

Maosheng Fang

Huazhong University of Science and Technology

Huqun Li

Huazhong University of Science and Technology

Taohua Sun

Qingdao University

Mingzhen Xu

University of Electronic Science and Technology of China

Zhongjian Zhang

Xinxiang Medical University

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University of Science and Technology of China

Chinese Academy of Sciences

Huazhong University of Science and Technology

Xinxiang Medical University

Capital Medical University

Union Hospital

Shanghai Jiao Tong University

University of Electronic Science and Technology of China

University of Chinese Academy of Sciences

Eunice Kennedy Shriver National Institute of Child Health and Human Development

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Single-Grain Detrital Apatite Sr Isotopic Composition as an Indicator to Trace Sedimentary Sources: A Case Study of Sedimentary Rocks in the Hui-Cheng Basin, South Qinling, China

Minerals (2023)

Risheng Ye Jingxin Zhao Zhiyi Wang Weiyong Li Jun He

Sediments or clastic rocks can record the evolution history of basins, orogenic processes, crustal uplift and erosion, and even paleo-environments. Detrital minerals such as zircon, garnet, and apatite are useful media for studies of sedimentary sources and basin evolution. Detrital zircon has been widely taken as an indicator for provenances and tectonic evolution of geological terrenes via age distribution patterns. Apatite can remain stable during erosion and transportation and is also considered as an ideal object for source tracing. This mineral normally contains high Sr and negligible Rb. Its Sr isotopic composition can remain almost unchanged after crystallization. Unlike isotopic ages of detrital minerals, Apatite isotopic compositions have been less frequently used for tracing the provenance of sedimentary rocks in the last few decades. In the present study, we report on the Sr isotopic composition of individual apatite grains of Neogene and Jurassic conglomerates from the Hui-Cheng basin in the South Qinling orogenic belt, obtained via thermal ionization mass spectrometry. Detrital apatite grains of Jurassic rocks have narrow ranges of 87Sr/86Sr values from 0.7076 to 0.7100, but those of Neogene rocks gave variant 87Sr/86Sr values from 0.7055 to 0.7534, providing distinct evidence for complex sources of Neogene sedimentary rocks. Analytical results show that the distribution patterns of 87Sr/86Sr values of single-grain detrital apatite fit the distribution patterns of detrital zircon U-Pb from the isotopic ages very well. Detrital apatite Sr isotopic composition can provide essential information for tracing the origins and evolution of sedimentary sources.

Neogene

10.3390/min13081010

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Partial melting of multiple mantle domains underneath the Paleo-Tethyan cold subduction zone triggered by slab rollback

Lithos (2023)

Xiguang Huang Jun He Jingxin Zhao Jingzhao Dou Weiyong Li

Crustal recycling

Adakite

Melt inclusions

10.1016/j.lithos.2023.107423

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Compositional Diversity of Early Mesozoic Granites in South Qinling: Derivation from Heterogenous Basement Rocks in the Orogenic Belt

Geosciences (2024)

Risheng Ye Weiyong Li Dongyang Huo Jingxin Zhao Xiguang Huang

Granitic rocks forming in the syn- to post-orogenic stages can trace the compositional and structural complexity of the crust beneath an orogenic belt. The Qinling orogenic belt undertook multiple stages of tectonics and magmatism, resulting in the multifaceted evolution and compositional diversity of the crust. In the present study, the Guangtoushan and Miba plutons in South Qinling were chosen to reveal the crustal heterogeneity in study area via isotopic geochemistry and zircon geochronology. The Guangtoushan pluton was emplaced between ~215 Ma and ~202 Ma and the Miba pluton formed at ~213 Ma, as constrained by zircon U-Pb isotopic dating. Granitic rocks of the Miba pluton are characterized by amphibole bearing and homogeneous composition, with relatively depleted Sr-Nd isotopic compositions (initial 87Sr/86Sr values of 0.7060 to 0.7084 and initial εNd values of −5.4 to −9.5) and high Pb isotopic values. The Guangtoushan pluton contains muscovite and complex inherited zircon grains and has variable Sr-Nd isotopic composition (initial 87Sr/86Sr values of 0.7050 to 0.7091 and initial εNd values of −4.5 to −12.9) and low Pb isotopic values. Felsic magmas of the Guangtoushan pluton should be derived mainly from meta-sedimentary rocks beneath South Qinling, while the Miba pluton originated primarily from partial melting of meta-igneous rocks. The compositional diversity recorded in the Early Mesozoic plutons was caused by the heterogeneous crust, and partial melting was induced by heating of the up-welling asthenosphere in a post-collision setting.

Basement

10.3390/geosciences14050138

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Chronic olanzapine administration causes metabolic syndrome through inflammatory cytokines in rodent models of insulin resistance

Scientific Reports (2019)

Huqun Li Shiyong Peng Shihong Li Shou‐Qing Liu Yifan Lv

Abstract Olanzapine is a second-generation anti-psychotic drug used to prevent neuroinflammation in patients with schizophrenia. However, the long-term administration of olanzapine leads to insulin resistance (IR); the mechanisms of this effect remains poorly understood. Using cellular and rodent models of IR induced by olanzapine, we found that chronic olanzapine treatment induces differential inflammatory cytokine reactions in peripheral adipose and the central nervous system. Long-term treatment of olanzapine caused metabolic symptoms, including IR, by markedly elevating the plasma levels of pro-inflammatory cytokines, including IL-1ß, IL-6, IL-8 and TNFα; these findings are consistent with observations from schizophrenia patients chronically treated with olanzapine. Our observations of differential inflammatory cytokine responses in white adipose tissues from the prefrontal cortex in the brain indicated cell type-specific effects of the drug. These cytokines induced IR by activating NF-kB through the suppression of IkBα. Functional blockade of the components p50/p65 of NF-kB rescued olanzapine-induced IR in NIH-3T3 L1-derived adipocytes. Our findings demonstrate that olanzapine induces inflammatory cytokine reactions in peripheral tissues without adversely affecting the central nervous system and suggest that chronic olanzapine treatment of schizophrenia patients may cause inflammation-mediated IR with minimal or no adverse effects in the brain.

10.1038/s41598-018-36930-y

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Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance

PLoS ONE (2016)

Huqun Li Maosheng Fang Mingzhen Xu Shihong Li Juan Du

Background Atypical antipsychotics such as olanzapine cause metabolic side effects leading to obesity and insulin resistance. The underlying mechanisms remain elusive. In this study we investigated the effects of chronic treatment of olanzapine on the fatty acid composition of plasma in mice. Methods Twenty 8-week female Balb/c mice were randomly assigned to two groups: the OLA group and the control group. After treatment with olanzapine (10 mg/kg/day) or vehicle intraperitoneally for 8 weeks, fasting glucose, insulin levels and oral glucose tolerance test were determined. Effects on plasma fatty acid profile and plasma indices of D5 desaturase, D6 desaturase and SCD1 activity were also investigated. Results Chronic administration of olanzapine significantly elevated fasting glucose and insulin levels, impaired glucose tolerance, but did not increase body weight. Total saturated fatty acids and n-6 polyunsaturated fatty acids were significantly increased and total monounsaturated fatty acids were significantly decreased, while total n-3 polyunsaturated fatty acids showed no prominent changes. Chronic olanzapine treatment significantly up-regulated D6 desaturase activity while down-regulating D5 desaturase activity. Palmitic acid (C16:0), dihomo-γ-linolenic acid (C20:3n-6) and D6 desaturase were associated with an increase probability of insulin resistance, whereas nervonic acid (C24:1) and SCD1 were significantly associated with a lower insulin resistance probability. Conclusions All results indicated that such drug-induced effects on fatty acid profile in plasma were relevant for the metabolic adverse effects associated with olanzapine and possibly other antipsychotics. Further studies are needed to investigate geneticand other mechanisms to explain how plasma fatty acids regulate glucose metabolism and affect the risk of insulin resistance.

10.1371/journal.pone.0167930

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Citations (10)