Lingli Sun

Guangdong Academy of Agricultural Sciences

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Xia Huang

State Key Joint Laboratory of Environment Simulation and Pollution Control

Jianhong Zhao

Second Hospital of Hebei Medical University

Shaolin Yang

North Minzu University

Chenyang Xu

Fudan University

Zhang Wei-hua

Southwest Jiaotong University

Ming Li

Northeastern University

Yihan Yang

Tsinghua University

Jianya Zhao

Nantong University

Taoli Han

Beijing Center for Disease Prevention and Control

Siqi Li

Northwest A&F University

Cooperative Institutions

Tsinghua University

State Key Joint Laboratory of Environment Simulation and Pollution Control

Chinese Academy of Medical Sciences & Peking Union Medical College

Nantong University

Beijing Center for Disease Prevention and Control

China Earthquake Administration

Chinese Academy of Sciences

Fudan University

Peking University

Sichuan University

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Evaluating approach uncertainties of quantitative detection of SARS-CoV-2 in wastewater: Concentration, extraction and amplification

The Science of The Total Environment (2024)

Shaolin Yang Yang Jiao Qian Dong Siqi Li Chenyang Xu

Primer (cosmetics)

Ultrafiltration (renal)

10.1016/j.scitotenv.2024.175285

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Citations (1)

Persistence of SARS-CoV-2 RNA in wastewater after the end of the COVID-19 epidemics

Journal of Hazardous Materials (2022)

Shaolin Yang Qian Dong Siqi Li Zhao Cheng Xiaofeng Kang

Pandemic

10.1016/j.jhazmat.2022.128358

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Citations (63)

Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Environmental Toxicology (2022)

Chunhua Wan Tianye Gu Junyi Ling Yi Qin Jiashan Luo

Perfluorooctane sulfonate (PFOS) is a widespread environmental pollutant and may cause a variety of adverse health effects. The hepatotoxicity of PFOS has attracted particular attention, given the fact that the liver has one of the highest PFOS accumulations among human tissues. In this study, we revealed that subchronic PFOS exposure may exacerbate carbon tetrachloride (CCl4 )-induced liver fibrosis in animal models. Administration with 1 mg/kg PFOS every other day for 56 days dramatically enhanced CCl4 -mediated liver injury and hepatic stellate cell (HSC) activation. Furthermore, PFOS exposure may promote the activation of high-mobility group box 1 (HMGB1)/toll-like receptor 4 (TLR4) signaling pathway through inducing the secretion of HMGB1 from hepatocytes. PFOS exposure induced the translocation of HMGB1 from the nucleus into the cytoplasm of hepatocytes and cultured BRL-3A cells at a starting concentration of 50 μM. This process is accompanied with concurrent flux of calcium, suggesting a link between calcium signaling and HMGB1 release following PFOS exposure. Finally, we showed that PFOS-exposed conditional medium (PFOS-CM) of hepatocytes may induce the translocation of Smad2/3 in HSCs in a TLR4-dependent manner. Taken together, subchronic PFOS exposure might play a pro-fibrotic role via a HMGB1/TLR4-dependent Smad signaling in HSCs. Our findings for the first time uncovered an involvement of PFOS exposure in liver fibrosis via HMGB1/TLR4/Smad signaling.

Perfluorooctane

HMGB1

Hepatic stellate cell

Steatosis

10.1002/tox.23458

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Citations (9)

Improving trans-cleavage activity of CRISPR-Cas13a using engineered crRNA with a uridinylate-rich 5′-overhang

Biosensors and Bioelectronics (2024)

Yihan Yang Lingli Sun Jianhong Zhao Yang Jiao Taoli Han

Trans-activating crRNA

Cleavage (geology)

10.1016/j.bios.2024.116239

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Citations (9)

Response of tilt and strain meters in Hubei province to the 2011 Mw9. 0 Japan earthquake

Geodesy and Geodynamics (2011)

Lingli Sun Ming Li Wei Guichun Luo Junqiu Zhang Wei-hua

Tilt and strain meters of the deformation-observation network in Hubei Province all responded to the Mw9. 0 Japan earthquake on March 11, 2011. By analyzing the co-seismic responses, we found that firstly there was essentially a linear correlation between response time and epicentral distance. Secondly, there was some correlation between maximum response amplitude and earthquake magnitude as well as between the duration and earthquake magnitude. Thirdly, the response amplitudes and decay rates were different for different types of instruments. Due to less data-sampling frequency, the deformation instruments, could not display the first motion of P and S waves, but responded mainly to far-field surface waves. Before the earthquake, the NS earth tide component recorded by the cave stainmeter at Yichang was distorted for nearly eight hours. While digital deformation observation did not show complete information about the earthquake source, it still reflected some key features of seismic-wave propagation.

10.3724/sp.j.1246.2011.00007.1

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