Weiming Liu

Soochow University

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Peirong Lu

Soochow University

Qiuke Wang

Shanghai Sixth People's Hospital

Yihong Cao

Weifang People's Hospital

Hao Dong

China University of Petroleum, Beijing

Jianping Guo

Chinese Academy of Meteorological Sciences

Wei Xia

Tianjin Medical University General Hospital

Yuehui She

Yangtze University

Lei Chen

Yangzhou University

İM

İbrahim M. Banat

University of Ulster

Yang Gao

Centre National de la Recherche Scientifique

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Soochow University

First Affiliated Hospital of Soochow University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Yangtze University

Sun Yat-sen University

University of Chinese Academy of Sciences

Weatherford College

Chongqing Medical University

China University of Geosciences (Beijing)

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Correlations among Diabetic Microvascular Complications: A Systematic Review and Meta-analysis

Scientific Reports (2019)

Jianqing Li Yihong Cao Weiming Liu Qiuke Wang Yifeng Qian

Early detection of diabetic microvascular complications is of great significance for disease prognosis. This systematic review and meta-analysis aimed to investigate the correlation among diabetic microvascular complications which may indicate the importance of screening for other complications in the presence of one disorder. PubMed, Embase, and the Cochrane Library were searched and a total of 26 cross-sectional studies met our inclusion criteria. Diabetic retinopathy (DR) had a proven risk association with diabetic kidney disease (DKD) [odds ratio (OR): 4.64, 95% confidence interval (CI): 2.47-8.75, p < 0.01], while DKD also related to DR (OR: 2.37, 95% CI: 1.79-3.15, p < 0.01). In addition, DR was associated with diabetic neuropathy (DN) (OR: 2.22, 95% CI: 1.70-2.90, p < 0.01), and DN was related to DR (OR: 1.73, 95% CI: 1.19-2.51, p < 0.01). However, the risk correlation between DKD and DN was not definite. Therefore, regular screening for the other two microvascular complications in the case of one complication makes sense, especially for patients with DR. The secondary results presented some physical conditions and comorbidities which were correlated with these three complications and thus should be paid more attention.

Diabetic Neuropathy

10.1038/s41598-019-40049-z

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Essential Contribution of Macrophage Tie2 Signalling in a Murine Model of Laser-Induced Choroidal Neovascularization

Scientific Reports (2020)

Xue Yin Bingyu Zhang Lei Chen Wei Xia Gaoqin Liu

Wet age-related macular degeneration (AMD), which can cause progressive blindness, is characterised by choroid neovascularization (CNV) in the macular area. Although close attention has been paid to AMD, and anti-vascular endothelial growth factor (VEGF) drugs are available, its complex pathogenesis is still elusive. Tie2-expressing macrophages (TEMs) have been found to promote angiogenesis in remodel tissues and tumours. This study aimed to elucidate the role of macrophage Tie2 signalling in laser-induced CNV (LCNV). We observed that TEMs were responsible for the severity of CNV. Mechanistically, TEM deletion resulted in impaired LCNV due to the suppression of inflammatory angiogenesis and the promotion of apoptosis. We also observed that TEMs prevented apoptosis of b.End3 cells, but promoted their migration, proliferation and tube formation via VEGF, extracellular signal-regulated kinase (ERK) and v-akt murine thymoma viral oncogene (AKT)-dependent signalling pathways. The flow cytometry results comparing dry AMD patients and healthy controls with wet AMD patients showed that the percentage of Tie2+CD14+ cells was higher in the wet AMD patients' peripheral blood. This study demonstrates that Tie2 expression by macrophages intensifies CNV in LCNV murine models, thereby proposing an additional intervention option to inhibit CNV.

Angiopoietin receptor

Signalling

10.1038/s41598-020-66580-y

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Effect of exotic species Mytilopsis sallei on macrozoobenthos in the Maluan Bay,Xiamen in China

Acta Oceanologica Sinica (2006)

Cai Li-zhe Yang Gao Weiming Liu Lin Xiu-chun Zhou Xiping

Balanus

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Elucidate microbial characteristics in a full-scale treatment plant for offshore oil produced wastewater

PLoS ONE (2021)

Shuyuan Deng Bo Wang Wenda Zhang Sanbao Su Hao Dong

Oil-produced wastewater treatment plants, especially those involving biological treatment processes, harbor rich and diverse microbes. However, knowledge of microbial ecology and microbial interactions determining the efficiency of plants for oil-produced wastewater is limited. Here, we performed 16S rDNA amplicon sequencing to elucidate the microbial composition and potential microbial functions in a full-scale well-worked offshore oil-produced wastewater treatment plant. Results showed that microbes that inhabited the plant were diverse and originated from oil and marine associated environments. The upstream physical and chemical treatments resulted in low microbial diversity. Organic pollutants were digested in the anaerobic baffled reactor (ABR) dominantly through fermentation combined with sulfur compounds respiration. Three aerobic parallel reactors (APRs) harbored different microbial groups that performed similar potential functions, such as hydrocarbon degradation, acidogenesis, photosynthetic assimilation, and nitrogen removal. Microbial characteristics were important to the performance of oil-produced wastewater treatment plants with biological processes.

Acidogenesis

Microbial consortium

10.1371/journal.pone.0255836

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Citations (4)