Driven by the CCMP(Cross-Calibrated,Multi-Platform) wind field data,the third-generation wave model WW3(WAVEWATCH Ⅲ) was used to simulate the wave field in the China Sea from January 10,2009 to January 16,2009.The observed wave data from Democratic People's Republic of Korea was first used to verify the model output.The results show that:(1) the WW3 wave model can properly reproduce the wave field caused by the cold air in the China Sea,and the simulated SWH(Significant Wave Height) agrees with the observation data.(2) The wave field is consistent with the wind field within the waters of the first island chain in the China Sea,but it’s not good in the outside region of the China Sea,especially in the east of the Philippines.h,which makes the sudden drop of sea surface temperature and sea ice is intensified.
This study aimed to investigate variations and relationships between molecular components and rheological properties during the long-term aging of SBS-modified asphalt by the action of moisture. The chemical components and changes in molecular weight during aqueous PAV aging were observed using a four-component test and GPC test, and these morphological changes were quantified. Viscosity tests, time-scan tests and damage-healing tests were carried out to investigate the rheological properties during the aging process. Finally, the mechanism of asphalt aging under the influence of moisture was discussed. The results showed that moisture facilitated the long-term aging of asphalt and complicated the aging behavior under pressure-aging conditions. The dissolution of certain hydrophilic groups may be responsible for the decrease in resin content. The fatigue and self-healing properties of asphalt were weakened by moisture during the aging process. This was mainly attributed to a decrease in the composition of the asphalt colloidal dispersion medium, which resulted in earlier and faster development of microcracks under repeated loading as well as retardation in the rate of asphalt surface approach, wetting and spreading. Under long-term aging in the presence of moisture, the molecular components of the asphalt showed significant correlations with the rheological properties. The results of this study can contribute to further explaining the influence of moisture on the thermal-oxidative aging of asphalt.
Objective: The study aimed to explore a new approach for the treatment of osteosarcoma through combining biomaterials with next-generation small molecule–based targeted therapy. Methods: The model of osteosarcoma was established by 4-hydroxyaminoquinoline 1-oxide (4-HAQO) in mice while the collagen-thermosensitive hydrogel–calcium phosphate (CTC) biocomposites were prepared, and the small molecule inhibitors were virtually screened and synthesized. Then, for the osteosarcoma cell line, MG-63 cells were used to validate our bioinformatic findings in vitro , and the mouse osteosarcoma models were treated by combing CTC composites and small-molecule inhibitors after debridement. Results: Five compounds, namely, ZINC150338698, ZINC14768621, ZINC4217203, ZINC169291448, and ZINC85537017, were found in the ZINK database. Finally, ZINC150338698 was selected for chemical synthesis and experimental verification. The results of the MTT assay and Hoechst staining showed that the small-molecule inhibitor ZINC150338698 could significantly induce MG-63 cell death. Furthermore, CTC composites and ZINC150338698 could repair the bone defects well after the debridement of osteosarcoma. In addition, the biomaterials and small-molecule inhibitors have good biocompatibility and biosafety. Conclusion: Our findings not only offer systems biology approach-based drug target identification but also provide new clues for developing novel treatment methods for future osteosarcoma research.
In this work, a review of the theory and application of heat and mass synergy is carried out. Since the field synergy theory was proposed, it has not only been greatly developed in the field of heat transfer but also has been explored and studied in the field of mass transfer and heat and mass synergy. In order to clarify the development and improvement process of field synergy theory and sort out its application and development trend, this paper conducts theoretical research on the proposal and controversy of field synergy theory and the derivation of the field synergy formula under different conditions. The field synergy equations based on different fluid states such as laminar flow and turbulent flow in the case of heat transfer, mass transfer, and heat–mass synergy are summarized. Optimizing the synergy application of heat–mass in engineering practice can significantly improve its heat and mass transfer capabilities. Although the field synergy principle has certain advantages in enhancing mass and heat transfer, it cannot take into account the power consumption in practical engineering applications. Therefore, combining the principle of field synergy with other theories to improve the comprehensive performance of heat and mass transfer has provided a way of thinking for future research.
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