Zongyi Yin

Shenzhen University

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Baifeng Li

China Medical University

Hao Li

Chinese PLA General Hospital

Zou Funian

First Hospital of China Medical University

Xin Wang

Jiujiang University

Ying Cheng

Northwest University

Zhang Jialin

First Hospital of China Medical University

Chen Dongying

First Hospital of China Medical University

Yongfeng Liu

Shenzhen Pingle Orthopedic Hospital

Gao Lianda

Chinese Academy of Geological Sciences

WU Guichun

Chinese Academy of Geological Sciences

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First Hospital of China Medical University

China Medical University

Czech Academy of Sciences, Institute of Geology

Chinese Academy of Geological Sciences

Chinese Academy of Sciences

Ministry of Natural Resources

Peking University

Institute of Geology and Geophysics

Bureau of Geology and Mineral Exploration and Development of Guizhou Province

China Geological Survey

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Risk factors of acute kidney injury after orthotopic liver transplantation in China

Scientific Reports (2017)

Zongyi Yin Baifeng Li Zou Funian Hao Li Xin Wang

Abstract In this study, we determined the risk factors for acute kidney injury (AKI) following orthotopic liver transplantation (OLT) in China. We collected 5074 donation after cardiac death (DCD) OLT recipients who underwent surgery between January 1, 2010, and December 31, 2015, in 86 academic hospitals or transplant centers in China. Univariate and multivariate analyses were used to investigate the criticality of donor, graft, or recipient variables in the development of post-OLT AKI. In all, 4482 patients were included (median age, 49.31 years). Post-OLT AKI occurred in 3.97% patients, and 73.6% of all OLT patients were male. The 1- and 5-year cumulative survival rates (CSRs) of the AKI group were 33.95% and 25.24%, respectively, compared with 86.34% and 70.05%, respectively, of the non-AKI group (P < 0.001). The independent risk factors for post-OLT AKI were blood loss, cold ischemia time, warm ischemia time, preoperative serum creatinine, the treatment period with dopamine, overexposure to calcineurin inhibitor, and combined mycophenolate mofetil use (P < 0.05). These had a high prediction accuracy for post-OLT AKI (area under the curve [AUC] = 0.740).

10.1038/srep41555

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Discovery of the Silurian chitinozoan fauna in the Mazha area, southern Yecheng, West Kunlun

Yao Jian-xin Xiao Xuchang Gao Lianda Wenhua Ji Zongyi Yin

The West Kunlun region is situated in a high-altitude cold, oxygen-deficient zone in the interior of Central Asia, where the level of geological research is relatively low. The determination of the stratigraphic age of the Lower Silurian low-grade metamorphic clastic rocks was mainly based on trilobites, corals and cephalopods, but no evidence of microfossils has been found. Recently abundant Silurian chitinozoan fossils of the genera Desmochitina,Sphaerochitina,Rhabdochitina and Conochitinas have been found during geological survey in the Wengquangou area, West Kunlun. This supplies the determination of the age of the Lower Silurian clastic rocks, geological survey in the West Kunlun region, stratigraphic division and correlation of the Silurian and research on the geological evolution in the West Kunlun region with important evidence of microfossil fossils.

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Correction: Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

PLoS ONE (2017)

Zongyi Yin Chen Dongying Baifeng Li

[This corrects the article DOI: 10.1371/journal.pone.0162099.].

10.1371/journal.pone.0170850

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Interleukin-35 mitigates the function of murine transplanted islet cells via regulation of Treg/Th17 ratio

PLoS ONE (2017)

Zongyi Yin Zou Funian Hao Li Xin Wang Ying Cheng

Pancreatic islet transplantation is a promising treatment for type 1 diabetes (T1D). Interleukin-35 (IL-35) is a recently discovered cytokine that exhibits potent immunosuppressive functions. However, the role of IL-35 in islet transplant rejection remains to be elucidated. In this study, we isolated islet cells of BALB/c mouse and purified CD4+ T cell subsets of a C57BL/6 mouse. The model for islet transplantation was established in vitro by co-culture of the islet cells and CD4+ T cells. IL-35 (20 ng/ml) was administered every other day. Following co-culture, the islet function and Treg/Th17 ratio were analyzed on days 1, 3, and 5. Furthermore, the Th17/Treg ratio was modulated (1:0–2), and the function of islet cells as well as proliferation of Th17 cells were analyzed. T cell sorting was performed using the magnetic bead sorting method; Treg and Th17 count using flow cytometry; cell proliferation detection using the carboxyfluorescein diacetate succinimidyl ester (CFSE) method, and islet function test using the sugar stimulation test. Results showed that Th17 counts increased in the co-culture system. However, after administration of IL-35, the number of Treg cells increased significantly compared to that in the control group (50.7% of total CD4+ T cells on day 5 in IL-35 group vs. 9.5% in control group) whereas the proliferation rate of Th17 cells was significantly inhibited (0.3% in IL-35 group vs. 7.2% in control group on day 5). Reducing the Th17/Treg ratio significantly improved the function of transplanted islets. Treg inhibited Th17 proliferation and IL-35 enhanced this inhibitory effect. IL-35 mitigates the function of murine transplanted islet cells via regulation of the Treg/Th17 ratio. This might serve as a potential therapeutic strategy for in-vivo islet transplant rejection and T1D.

Cell Sorting

10.1371/journal.pone.0189617

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A rapid, efficient, and economic device and method for the isolation and purification of mouse islet cells

PLoS ONE (2017)

Zongyi Yin Zou Funian Hao Li Ying Cheng Zhang Jialin

Rapid, efficient, and economic method for the isolation and purification of islets has been pursued by numerous islet-related researchers. In this study, we compared the advantages and disadvantages of our developed patented method with those of commonly used conventional methods (Ficoll-400, 1077, and handpicking methods). Cell viability was assayed using Trypan blue, cell purity and yield were assayed using diphenylthiocarbazone, and islet function was assayed using acridine orange/ethidium bromide staining and enzyme-linked immunosorbent assay-glucose stimulation testing 4 days after cultivation. The results showed that our islet isolation and purification method required 12 ± 3 min, which was significantly shorter than the time required in Ficoll-400, 1077, and HPU groups (34 ± 3, 41 ± 4, and 30 ± 4 min, respectively; P < 0.05). There was no significant difference in islet viability among the four groups. The islet purity, function, yield, and cost of our method were superior to those of the Ficoll-400 and 1077 methods, but inferior to the handpicking method. However, the handpicking method may cause wrist injury and visual impairment in researchers during large-scale islet isolation (>1000 islets). In summary, the MCT method is a rapid, efficient, and economic method for isolating and purifying murine islet cell clumps. This method overcomes some of the shortcomings of conventional methods, showing a relatively higher quality and yield of islets within a shorter duration at a lower cost. Therefore, the current method provides researchers with an alternative option for islet isolation and should be widely generalized.

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Isolation

10.1371/journal.pone.0171618

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Global Regulatory T-Cell Research from 2000 to 2015: A Bibliometric Analysis

PLoS ONE (2016)

Zongyi Yin Chen Dongying Baifeng Li

We aimed to analyze the global scientific output of regulatory T-cell (Treg) research and built a model to qualitatively and quantitatively evaluate publications from 2000 to 2015. Data were obtained from the Web of Science Core Collection (WoSCC) of Thomson Reuters on January 1, 2016. The bibliometric method and Citespace III were used to analyze authors, journals, publication outputs, institutions, countries, research areas, research hotspots, and trends. In total, we identified 35,741 publications on Treg research from 2000 to 2015, and observed that the annual publication rate increased with time. The Journal of Immunology published the highest number of articles, the leading country was the USA, and the leading institute was Harvard University. Sakaguchi, Hori, Fontenot, and Wang were the top authors in Treg research. Immunology accounted for the highest number of publications, followed by oncology, experimental medicine, cell biology, and hematology. Keyword analysis indicated that autoimmunity, inflammation, cytokine, gene expression, foxp3, and immunotherapy were the research hotspots, whereas autoimmune inflammation, gene therapy, granzyme B, RORγt, and th17 were the frontiers of Treg research. This bibliometric analysis revealed that Treg-related studies are still research hotspots, and that Treg-related clinical therapies are the research frontiers; however, further study and collaborations are needed worldwide. Overall, our findings provide valuable information for the editors of immunology journals to identify new perspectives and shape future research directions.

Web of science

10.1371/journal.pone.0162099

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Citations (41)