Yanan Zhang

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

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Xudong Qu

Wuhan University

Zixin Deng

Wuhan University

Yongjia Shang

Anhui Normal University

Eric C. D. Tan

National Renewable Energy Laboratory

Mary J. Biddy

Oak Ridge National Laboratory

Dongqing Zhu

Wuhan University

Peng‐Lin Wei

Institute of Microbiology

Mehdi Mobli

University of Queensland

Shi‐Lu Chen

Hunan University of Technology

Xinying Jia

National University of Singapore

Cooperative Institutions

Wuhan University

Shanghai Jiao Tong University

National Renewable Energy Laboratory

Chinese Academy of Sciences

Shanghai Advanced Research Institute

Pacific Northwest National Laboratory

National Technical Information Service

Office of Scientific and Technical Information

Argonne National Laboratory

Idaho National Laboratory

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Economic and environmental potentials for natural gas to enhance biomass-to-liquid fuels technologies

Green Chemistry (2018)

Yanan Zhang Asad H. Sahir Eric C. D. Tan Michael Talmadge Ryan Davis

With the increased availability of low-cost natural gas, co-conversion of natural gas and biomass-to-liquid fuels has gained interest due to the potential to improve liquid fuel yields while lowering greenhouse gas emissions.

Liquid fuel

Renewable natural gas

Substitute natural gas

10.1039/c8gc01257a

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Citations (37)

Willingness to Pay for Green Office: Evidence from Shanghai

Environmental Science and Pollution Research (2022)

Yanan Zhang Haitao Yin

Promotion (chess)

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Mixed logit

Consumption

10.1007/s11356-022-21555-6

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Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Nature Communications (2018)

Wenya Tian Chenghai Sun Mei Zheng Jeffrey R. Harmer Mingjia Yu

Abstract Many natural products contain the hexahydropyrrolo[2, 3- b ]indole (HPI) framework. HPI containing chemicals exhibit various biological activities and distinguishable structural arrangement. This structural complexity renders chemical synthesis very challenging. Here, through investigating the biosynthesis of a naturally occurring C 3 -aryl HPI, naseseazine C (NAS-C), we identify a P450 enzyme (NascB) and reveal that NascB catalyzes a radical cascade reaction to form intramolecular and intermolecular carbon–carbon bonds with both regio- and stereo-specificity. Surprisingly, the limited freedom is allowed in specificity to generate four types of C 3 -aryl HPI scaffolds, and two of them were not previously observed. By incorporating NascB into an engineered strain of E. coli , we develop a whole-cell biocatalysis system for efficient production of NAS-C and 30 NAS analogs. Interestingly, we find that some of these analogs exhibit potent neuroprotective properties. Thus, our biocatalytic methodology offers an efficient and simple route to generate difficult HPI framework containing chemicals.

Synthetic Biology

10.1038/s41467-018-06528-z

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Citations (71)

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Nature Communications (2019)

Junlin Wang Yanan Zhang Huanhuan Liu Yongjia Shang Linjun Zhou

Abstract Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale. The obtained C 19 -OH-cortexolone can be readily transformed to various synthetically useful intermediates including the industrially valuable 19-OH-androstenedione, which can serve as a basis for synthesis of C19-functionalized steroids as well as 19-nor steroidal drugs. Using this biocatalytic C19-hydroxylation method, the unified synthesis of six C19-hydroxylated pregnanes is achieved in just 4 to 9 steps. In addition, the structure of sclerosteroid B is revised on the basis of our synthesis.

Hydroxylation

Biotransformation

10.1038/s41467-019-11344-0

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Citations (44)