Chang Wang

Icahn School of Medicine at Mount Sinai

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Fan Yang

Jiangxi Agricultural University

Zejing Wei

Jiangxi Agricultural University

Caiying Zhang

Nanyang Normal University

Shaoxing Pi

Jiangxi Agricultural University

Qiliang Sun

Nanjing Forestry University

Guoliang Hu

University of Science and Technology of China

Gaohui Nie

Jiangxi College of Applied Technology

Minoru Takeuchi

Kyoto Sangyo University

Xinong Xie

Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)

Bruce D. Hammock

University of California, Davis

Cooperative Institutions

Chinese Academy of Sciences

Icahn School of Medicine at Mount Sinai

Tianjin University

Allen Institute for Brain Science

Tisch Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Jiangxi Agricultural University

Zhejiang University

The Ohio State University

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Solvent Effects on Catechol Crystal Habits and Aspect Ratios: A Combination of Experiments and Molecular Dynamics Simulation Study

Crystals (2020)

Dan Zhu Shihao Zhang Pingping Cui Chang Wang Jiayu Dai

This work could help to better understand the solvent effects on crystal habits and aspect ratio changes at the molecular level, which provide some guidance for solvent selection in industrial crystallization processes. With the catechol crystal habits acquired using both experimental and simulation methods in isopropanol, methyl acetate and ethyl acetate, solvent effects on crystal morphology were explored based on the modified attachment energy model. Firstly, morphologically dominant crystal faces were obtained with the predicted crystal habit in vacuum. Then, modified attachment energies were calculated by the molecular dynamics simulation to modify the crystal shapes in a real solvent environment, and the simulation results were in agreement with the experimental ones. Meanwhile, the surface properties such as roughness and the diffusion coefficient were introduced to analyze the solvent adsorption behaviors and the radial distribution function curves were generated to distinguish diverse types of interactions like hydrogen bonds and van der Waals forces. Results show that the catechol crystal habits were affected by the combination of the attachment energy, surface structures and molecular interaction types. Moreover, the changing aspect ratios of catechol crystals are closely related to the existence of hydrogen bonds which contribute to growth inhibition on specific faces.

Crystal (programming language)

Crystal habit

Catechol

Interaction energy

10.3390/cryst10040316

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Citations (19)

LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing

Nature Communications (2024)

Yonger Xue Yuebao Zhang Yichen Zhong Shi Du Xucheng Hou

Abstract Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a challenge in achieving optimal therapeutic outcomes. Herein, we conceive a series of lipid nanoparticles to reprogram ASCs with durable protein secretion capacity for enhanced tissue engineering and regeneration. In vitro studies identify that the isomannide-derived lipid nanoparticles (DIM1T LNP) efficiently deliver RNAs to ASCs. Co-delivery of self-amplifying RNA (saRNA) and E3 mRNA complex (the combination of saRNA and E3 mRNA is named SEC) using DIM1T LNP modulates host immune responses against saRNAs and facilitates the durable production of proteins of interest in ASCs. The DIM1T LNP-SEC engineered ASCs (DS-ASCs) prolong expression of hepatocyte growth factor (HGF) and C-X-C motif chemokine ligand 12 (CXCL12), which show superior wound healing efficacy over their wild-type and DIM1T LNP-mRNA counterparts in the diabetic cutaneous wound model. Overall, this work suggests LNPs as an effective platform to engineer ASCs with enhanced protein generation ability, expediting the development of ASCs-based cell therapies.

10.1038/s41467-024-45094-5

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Citations (25)

Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis alleviates excess molybdenum-induced apoptosis in duck renal tubular epithelial cells

Ecotoxicology and Environmental Safety (2020)

Shaoxing Pi Gaohui Nie Zejing Wei Fan Yang Chang Wang

Excess molybdenum (Mo) is harmful to the body, and the kidney is the vital target organ for Mo exposure. This study focused on the impacts of excess Mo on pyroptosis and the relationship between pyroptosis and apoptosis in kidney. The duck renal tubular epithelial cells were treated with (NH4)6Mo7O24·4H2O (0, 480, 720 and 960 μM Mo), N-acetyl-L-cysteine (NAC) (100 μM), Z-YVAD-fluoromethylketone (YVAD) (10 μM) and the combination of Mo and NAC or YVAD for 12 h. The LDH release and IL-1β, IL-18 contents of cell supernatant were detected by LDH and ELISA kits. The MMP and ROS level were measured using MMP and ROS kits by flow cytometry. The apoptotic rate of cell was detected by AO/EB counterstaining. Pyroptosis and apoptosis-related factors mRNA and protein levels were assayed by real-time qPCR and western blot, respectively. Excessive Mo markedly increased LDH, IL-18, IL-1β releases and induced overproduction of ROS, pyroptosis-related factors mRNA and protein levels. NAC and YVAD dramatically decreased pyroptosis induced by Mo. Simultaneously, YVAD significantly changed apoptosis-related factors mRNA and protein levels, and reduced cell apoptotic rate. Excessive Mo exposure can induce pyroptosis by the ROS/NLRP3/Caspase-1 pathway in duck renal tubular epithelial cells, and restraining pyroptosis of Caspase-1 dependence might weaken excess Mo-induced apoptosis. The study provides theoretical basis for excess Mo exposure nephrotoxic researches on waterfowl and the interplay between pyroptosis and apoptosis highlights a new sight into the mechanism of Mo-induced nephrotoxicity.

Pyroptosis

10.1016/j.ecoenv.2020.111528

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Sill swarms and hydrothermal vents in the Qiongdongnan Basin, northern South China Sea

Geosystems and Geoenvironment (2022)

Qiliang Sun Chang Wang Xinong Xie

Sills and hydrothermal vents are commonly observed in sedimentary basins. However, not all sills could generate overlying hydrothermal vents, and whether a sill generates a hydrothermal vent or not is still poorly constrained. In this study, a large number of sills and hydrothermal vents are observed, using high-resolution reflection seismic data in the Qiongdongnan Basin of northern South China Sea. These sills are characterized by saucer or linear shapes and present as isolated sills or sill swarms, roughly being larger with buried depth increase. More importantly, the hydrothermal vents are mainly related to the underlying sills intruding into the shallow strata (buried depth <1.4 km), which suggests that magma intrusion depth (from paleo-seabed to the tip of sill) plays an important role on the formation of hydrothermal vents. The duration of magmatism lasted for ∼5 Ma from ∼11.6 Ma to ∼5.7 Ma with peak occurring at ∼8.2 Ma, judging from the spans of hydrothermal vents in the sedimentary strata. This study reports the intense magmatism in the eastern Qiongdongnan Basin for the first time, which extends the distribution of post-rift magmatism in the South China Sea and benefits to explore the mysterious origin of post-rift magmatism. The intense magmatism would also influence the maturity of source rock and hydrocarbon migration in such a petroliferous basin. Moreover, this study also highlights that shallow emplacement of sill is advantageous for the occurrence of hydrothermal vents due to the heating of unconsolidated/less consolidated strata by magmatic sills.

Sill

10.1016/j.geogeo.2022.100037

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Citations (14)

Metabolism of cyanide by Chinese vegetation

Chemosphere (2004)

Xiao-Zhang Yu Stefan Trapp Puhua Zhou Chang Wang Xishi Zhou

10.1016/j.chemosphere.2004.02.008

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Citations (55)

Sediment deformation triggered by underlying magma intrusion

Journal of Asian Earth Sciences (2021)

Chang Wang Qiliang Sun Xinong Xie

10.1016/j.jseaes.2021.105045

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Citations (5)

Plasma proteomic study of acute mountain sickness susceptible and resistant individuals

Scientific Reports (2018)

Hui Lu Rong Wang Wenbin Li Hua Xie Chang Wang

Abstract Although extensive studies have focused on the development of acute mountain sickness (AMS), the exact mechanisms of AMS are still obscure. In this study, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis to identify novel AMS−associated biomarkers in human plasma. After 9 hours of hypobaric hypoxia the abundance of proteins related to tricarboxylic acid (TCA) cycle, glycolysis, ribosome, and proteasome were significantly reduced in AMS resistant (AMS−) group, but not in AMS susceptible (AMS+) group. This suggested that AMS− individuals could reduce oxygen consumption via repressing TCA cycle and glycolysis, and reduce energy consumption through decreasing protein degradation and synthesis compared to AMS+ individuals after acute hypoxic exposure. The inflammatory response might be decreased resulting from the repressed TCA cycle. We propose that the ability for oxygen consumption reduction may play an important role in the development of AMS. Our present plasma proteomic study in plateau of the Han Chinese volunteers gives new data to address the development of AMS and potential AMS correlative biomarkers.

Hypoxia

Tandem mass tag

10.1038/s41598-018-19818-9

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Citations (23)

Multi-camera vision-based synchronous positioning and mapping for green construction of electric substations

Frontiers in Energy Research (2024)

Chang Wang Huihong Yuan Qifeng Bian Chongjuan Zhao Botao Zhou

Accurate CO 2 tracking in electric substation construction is vital for climate efforts, using monocular SLAM for monitoring despite challenges like sunlight and complex terrain. Additionally, these methods typically yield only aggregate carbon emission data, thereby lacking the granularity necessary for precise monitoring throughout the construction process. These limitations compromise mapping accuracy and impede the integration of digital twins and IoT technologies. Addressing these issues, this paper proposed a methodology combining red, green, and blue (RGB) cameras and multi-camera collaboration with digital design systems, enhancing SLAM capabilities. The advanced technique integrated methods including overlap estimation, depth reasoning, noise reduction, and surface reconstruction to create accurate 3D models, enhancing scene reconstruction and real-time CO 2 tracking during construction and operation. Leveraging continuous on-site camera monitoring as a substitute for manual inspections, it significantly contributes to the compilation of a comprehensive carbon emission database within a digital twin framework. Experimental results confirmed the proposed method’s superiority over previous works in real-time CO 2 estimation, enhancing decision-making, resource management, and sustainable energy development. Overall, besides its application in substation construction for CO 2 monitoring, this methodology can also be applied to carbon tracking in various other construction projects.

10.3389/fenrg.2024.1370873

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Citations (2)

Clinical efficacy and safety of platelet-rich plasma in arthroscopic full-thickness rotator cuff repair: A meta-analysis

PLoS ONE (2019)

Chang Wang Meng Xu Wenlai Guo Yaodong Wang Shishun Zhao

Arthroscopic repair of rotator cuff tears, although commonly performed, carries the risk of retears. Therefore, bioremediation techniques such as platelet-rich plasma injections have been used as adjuvant therapies. The clinical efficacy of platelet-rich plasma in the arthroscopic repair of full-thickness rotator cuff injury is controversial. We performed a meta-analysis to evaluate the clinical effectiveness and safety of platelet-rich plasma and provide evidence-based medical recommendations for selecting the proper clinical treatment plan for full-thickness rotator cuff injuries.

Rotator cuff injury

10.1371/journal.pone.0220392

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Citations (32)

Thermal runaway behaviors of Li-ion batteries after low temperature aging: Experimental study and predictive modeling

Journal of Energy Storage (2023)

Senming Wu Chang Wang Weiling Luan Yulong Zhang Ying Chen

Thermal Runaway

10.1016/j.est.2023.107451

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Citations (28)