The domestic economy has been developing very fast, which gears up the developing of cities, and brings lots of problems to the cities. This essay introduces the foreign theories and research directions of the developing of cities. It analysis the status quo of domestic urban spatial layout, and discovers problems and defects of it, and furthermore, brings up methods and patterns to improve the domestic urban spatial layout, by balancing distribution of resources, rationalizing the design of transportation, sustaining the ecological environment, intensifying the land utilization, as the pattern of domestic city development in the future.
To explore the clinical characteristics of patients infected with SARS-CoV-2 nationwide, especially the effect factors of asymptomatic infection and disappearance of clinical symptoms. A total of 66,448 COVID-19 patients in China who have been diagnosed by nucleic acid test or rapid antigen test were surveyed online (December 24, 2022 to January 16, 2023). Our cross-sectional study used descriptive analyses and binary Logistics regression model to assess the correlation between the clinical characteristics and relative factors, including age, gender, pre-existing conditions, reinfection, vaccination and treatment. A total of 64,515 valid questionnaires were collected. Among included participants, 5969 of which were asymptomatic. The symptoms were mainly upper respiratory symptoms, including dry and itchy throat (64.16%), sore throat (59.95%), hoarseness (57.90%), nasal congestion (53.39%). In binary Logistics regression model, we found that male, no pre-existing conditions, reinfection and vaccination have positive correlations with the appearance of asymptomatic COVID-19 patients. In Cox proportional-hazards regression model, considering all clinical symptoms disappeared in 14 days as outcome, we found that ≤ 60 years old, male, no pre-existing conditions, vaccination and adopted treatment have positive correlations with rapid amelioration of clinical symptoms in COVID-19 patients. The clinical symptoms of the participants were mainly upper respiratory symptoms which were according with the infection of Omicron variant. Factors including age, gender, pre-existing conditions and reinfection could influence the clinical characteristics and prognosis of COVID-19 patients. Importantly, vaccination has positive significance for the prevention and treatment of COVID-19. Lastly, the use of Chinese medicine maybe beneficial to COVID-19 patients, however, reasonable guidance is necessary.
Abstract Civic honesty is a crucial behavior that policymakers and business leaders strive to promote among citizens and employees. We conducted online and field experiments in China adapting the setting of a recent research which employed an innovative design to study civic honesty behavior around the globe. Results show that the psychological mechanism underlying lost-wallet reporting behavior in China is somewhat different from what has been suggested in the literature. Chinese participants indicated they are significantly more likely to put WeChat than email as contact information on their lost items, corroborating a local norm in China that email is infrequently used by ordinary Chinese citizens. Moreover, we tested multiple behavioral interventions in the field. Aiding a lost-property finder to connect to an owner using WeChat led to a reporting rate of 59.3% (vs. 7% as shown in a recent research that used email as the communication means; note that due to differences in experimental designs, no direct comparison of these reporting rates should be made however). Our research suggests that interacting with citizens from a targeted population to formulate locally informed research questions and design may be crucial for understanding and promoting civic honesty behavior.
Abstract In this study, the plane wave exposure of an infant to radiofrequency electromagnetic fields of 3.5 GHz was numerically analyzed to investigate the unintentional electromagnetic field (EMF) exposure of fifth generation (5G) signals during field test. The dosimetric influence of age‐dependent dielectric properties and the influence of an adult body were evaluated using an infant model of 12 month old and an adult female model. The results demonstrated that the whole body‐averaged specific absorption rate (WBASAR) was not significantly affected by age‐dependent dielectric properties and the influence of the adult body did not enhance WBASAR. Taking the magnitude of the in situ E field strength into consideration, realistic WBASAR was far below the basic restriction. Age‐dependent dielectric properties could significantly change the tissue specified specific absorption rate (TSSAR) of internal organs. However, the variation was not significant because the absolute values were marginal. Among the factors that influenced TSSAR variation, change in dielectric properties demonstrated a close correlation. In general, at 3.5 GHz, the infant did not absorb more power than the case of EMF exposure to third generation (3G) and fourth generation (4G) signals. The work was helpful for network operators and device manufactures to estimate the potential exposure risk during the field test, especially for the infant.
Small artery occlusion (SAO) is responsible for 31.3% of all ischemic strokes in China. However, reports regarding the recurrence rate of SAO in China are rare. We aimed to assess the recurrence rate and factors associated with SAO in China. All consecutive patients with SAO hospitalized at Tianjin Huanhu Hospital from 2005 to 2014 were recruited. We assessed the association between stroke subtype, severity, and disease history with recurrence at 3, 12, and 36 months of onset using multivariate logistic regression analysis. A total of 2,524 SAO patients were included in this study, including 1696 (67.2%) men and 828 (32.8%) women. The recurrence rates were 3.1% at 3 months, 12.7% at 12 months, and 36.5% at 36 months. Compared with women, men had a higher risk of recurrence at 3 months after SAO (P = 0.003). Old age and severity of stroke were also associated with a higher risk of recurrence (P < 0.05). Patients with an elevated C-reactive protein had a higher risk of recurrence at 12 months (P = 0.003). On the other hand, the risk of recurrence at 12 months was 39% lower in patients who consumed alcohol than in those who did not (P = 0.037). Hypertension, atrial fibrillation, and obesity were independent risk factors of recurrence at 36 months. These findings suggest that modification of risk factors in patients with SAO, particularly men, is essential for reducing the rate of recurrence and the overall burden of stroke in China.
Epidemic methicillin-resistant Staphylococcus aureus (MRSA) imposes an increasing impact on public health. Due to multi-antibiotics resistance in MRSA strains, there is an urgent need to develop novel therapeutics such as effective monoclonal antibodies (mAbs) against MRSA infections. Staphylococcus aureus surface protein A (SasA), a large surface-located protein (~240 kDa), is one of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and a potential target for immunotherapeutic approaches against S. aureus infections. In the present study, we analyzed the sequence of SasA with bioinformatics tools and generated a protective monoclonal antibody (2H7) targeting the conserved domain of SasA. 2H7 was shown to recognize wild-type S. aureus and promote opsonophagocytic killing of S. aureus. In both sepsis and peritoneal infection models, prophylactic administration of 2H7 improved the survival of BALB/c mice challenged by S. aureus strain USA300 and ST239 (prevalent MRSA clones in North America and Asian countries, respectively) and enhanced bacterial clearance in kidneys. Additionally, 2H7 prophylaxis prevented the formation of intraperitoneal abscess in a murine model of peritoneal infection and therapeutic administration of 2H7 showed protective efficacy in a murine sepsis model. Our results presented here provide supporting evidences that an anti-SasA mAb might be a potential component in an antibody-based immunotherapeutic treatment of MRSA infections.
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