Saı̈d Kamel

Farwaniya Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Rachida Mahjoubi

Université Moulay Ismail de Meknes

Ziad A. Massy

Hôpital Ambroise-Paré

Hanoun Ibouhouten

Université Moulay Ismail de Meknes

Joachim W. Härtling

Osnabrück University

Abdeslam Mikdad

Institut National des Sciences de l'Archéologie et du Patrimoine

Jörg Linstädter

Deutsches Archäologisches Institut, Kommission für Archäologie Außereuropäischer Kulturen

Katrin Fenech

University of Malta

Petra Werner

TH Köln - University of Applied Sciences

Jens Bussmann

Osnabrück University

Gabriel Choukroun

Centre Hospitalier Universitaire Amiens-Picardie

Cooperative Institutions

Université de Picardie Jules Verne

Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires

Physiopathologie et Epidémiologie des Maladies Respiratoires

Centre Hospitalier Universitaire Amiens-Picardie

Inserm

Centre National de la Recherche Scientifique

RELX Group (United States)

Université Moulay Ismail de Meknes

Osnabrück University

Instituto Superior da Maia

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Sr isotopic tracing in a lagoonal system : example of surficial carbonate sediments in the Nador lagoon (northeastern Morocco)

BSGF – Earth Sciences Bulletin (2005)

Rachida Mahjoubi Saı̈d Kamel Y. Noack Annie Michard Daniel Nahon

Abstract The Nador lagoon is the largest one in Morocco and along the Mediterranean. It is located on the northeastern coast near the Rif chain (North Morocco), and it is surrounded by volcanic and sedimentary rocks of various lithofacies. The watershed has an area of about 2200 km2 and is drained by a dense river network. The lagoon dimension is of 115 km2 (25 x 7.5 km) with a depth not exceeding 8 m. The island barrier is 25 km in length and 350 m in average width. The carbonate fraction is the dominant component of the present-day sedimentation in the Nador lagoon. It represents 13 to 48 % of total sediments. Its distribution within the lagoon reflects the nature of marine and continental watershed. The carbonate fraction is composed, in decreasing order of importance, of calcite, magnesium calcite, dolomite and aragonite. The Sr isotopic signatures of lagoonal carbonates sediments show that they are dominated by marine biogenic sediments deposited, and by chemical precipitation. In addition, other carbonates of external origin and less radiogenic Sr isotopic are also present, coming from aerosols and ancient carbonates and transported by streams and rivers. From northwest to southeast, the Sr concentration of these lagoon carbonates increases, showing a slow renewal of waters in the southeastern zone because of its remoteness from communication with sea.

Subaerial

10.2113/176.4.373

Cite

Citations (1)

Holocene alluvial archives and human occupation in the Lower Moulouya River (north-eastern Morocco)

Hanoun Ibouhouten Christoph Zielhofer Rachida Mahjoubi Saı̈d Kamel Jörg Linstädter

Source

Cite

Citations (0)

Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease

Scientific Reports (2021)

Maria Grissi Cédric Boudot Maryam Assem Alexandre Candellier Mathilde Lando

Abstract Chronic kidney disease (CKD) worsens ischemic stroke severity in both patients and animals. In mice, these poorer functional outcomes are associated with decreased brain activity of AMP-activated protein kinase (AMPK), a molecule that recently emerged as a potential therapeutic target for ischemic stroke. The antidiabetic drug metformin, a well-known activator of AMPK, has improved stroke outcomes in diabetic patients with normal renal function. We investigated whether chronic metformin pre-conditioning can rescue AMPK activity and prevent stroke damage in non-diabetic mice with CKD. Eight-week-old female C57BL/6J mice were assigned to CKD or SHAM groups. CKD was induced through right kidney cortical electrocautery, followed by left total nephrectomy. Mice were then allocated to receive metformin (200 mg/kg/day) or vehicle for 5 weeks until stroke induction by transient middle cerebral artery occlusion (tMCAO). The infarct volumes were lower in CKD mice exposed to metformin than in vehicle-treated CKD mice 24 h after tMCAO. Metformin pre-conditioning of CKD mice improved their neurological score, grip strength, and prehensile abilities. It also enhanced AMPK activation, reduced apoptosis, increased neuron survival and decreased microglia/macrophage M 1 signature gene expression as well as CKD-induced activation of the canonical NF-κB pathway in the ischemic lesions of CKD mice.

Stroke

10.1038/s41598-021-86905-9

Cite

Citations (14)

Lineaments frequencies from Landsat ETM + of the Middle Atlas Plateaus (Morocco)

My Hachem Aouragh Ali Essahlaoui Abdelhadi El Ouali Abdellah El Hmaidi Saı̈d Kamel

A lineament analysis of Middle Atlas Plateaus was carried out by interpretation of ETM+ images acquired by Landsat 7 satellite. The features of geological interest detected during the interpretation process were digitized using a raster-based GIS software. Synthesis map of lineaments was produced from combining four methods; filtering techniques, color compositions, ratios bands and principal components analysis (PCA). In the study area, knowledge of structural lineaments is very interesting to identify areas suitable for circulation of groundwater. A spatial statistic analysis of the lineaments was performed to detect their frequency and main direction, helped then to identify interesting technical for extraction lineaments.

Lineament

Source

Cite

Citations (4)

Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease

Scientific Reports (2019)

Lucie Hénaut Maria Grissi François Brazier Maryam Assem Sabrina Poirot-Leclercq

Abstract Ischemic stroke is highly prevalent in chronic kidney disease (CKD) patients and has been associated with a higher risk of neurological deterioration and in-hospital mortality. To date, little is known about the processes by which CKD worsens ischemic stroke. This work aimed to investigate the cellular and molecular mechanism associated with ischemic stroke severity in an in vivo model of CKD. CKD was induced through right kidney cortical electrocautery in 8-week-old female C57BL/6 J mice followed by left total nephrectomy. Transient middle cerebral artery occlusion (tMCAO) was performed 6 weeks after left nephrectomy. Twenty-four hours after tMCAO, the infarct volumes were significantly wider in CKD than in SHAM mice. CKD mice displayed decreased neuroscore, impaired ability to remain on rotarod device, weaker muscular strength and decreased prehensile score. Apoptosis, neuronal loss, glial cells recruitment and microglia/macrophages M 1 signature genes CD32, CD86, IL-1β, IL-6, MCP1 and iNOS were significantly increased within ischemic lesions of CKD mice. This effect was associated with decreased AMP kinase phosphorylation and increased activation of the NFΚB pathway. Pharmacological targeting of AMP kinase activity, which is known to block microglia/macrophages M 1 polarization, appears promising to improve stroke recovery in CKD.

Stroke

10.1038/s41598-019-42933-0

Cite

Citations (25)

NATURE, ORIGINE ET RÉPARTITION DE LA PHASE ARGILEUSE DE LA LAGUNE DE NADOR (MAROC NORD ORIENTAL)

Geologica Belgica (2007)

Rachida Mahjoubi Saı̈d Kamel Bouchta El Moumni Y. Noack Claude Parrón

La lagune de Nador est situee a l'extremite Est du Rif Nord Oriental marocain. Elle est encadree par des formations a facies tres varies. La phase argileuse des sediments de la lagune comporte, par ordre d'importance decroissant, l'illite, la kaolinite, la smectite et la chlorite. La smectite caracterise la partie NE de la lagune et la chlorite caracterise la zone SE. Dans le bassin versant, l'illite, ubiquiste, et la chlorite se rencontrent dans toutes les formations sedimentaires; elles abondent dans les marnes jurassiques de Kebdana et dans les schistes jurassiques de Bni Bou Ifrour. La kaolinite se developpe par alteration des differents substrats geologiques. La smectite est liberee par les marnes miocenes et jurassiques et surtout par les formations superficielles, notamment les alterites et les sols des roches volcaniques de Gourougou. La phase argileuse des matieres en suspension et des alluvions des tributaires montrent un enrichissement en smectite en allant du Sud vers le Nord du bassin versant avec un enrichissement en illite dans les matieres en suspension. A ces apports continentaux s'ajoutent ceux des aerosols dont la composition mineralogique, comporte les quatre mineraux principaux avec des teneurs qui changent en fonction des saisons. Dans la lagune, la repartition des argiles dominees par les materiaux du substrat, est controlee par la nature des apports et par les courants intralagunaires. Les apports en argiles n'ont pas beaucoup change au cours du temps (3000 ans) et l'evolution des argiles, dans le remplissage du bassin, est liee a la dynamique lagunaire qui est controlee par le changement de la position du chenal de communication.

Illite

Source

Cite

Citations (11)

Das MICA-Allel 5.1 ist assoziiert mit Zöliakie und ist an der apiko-lateralen Membran intestinaler Epithelzellen lokalisiert

Zeitschrift für Gastroenterologie (2010)

Michael Schümann Saı̈d Kamel J-D Schulzke S Daum

Hintergrund: MICA ist ein nicht-klassisches MHCI-Molekül, dem eine besondere Bedeutung in der Immunantwort bei Zöliakie zukommt. Die Interaktion mit auf intraepithelialen Lymphozyten exprimierten NKG2D-Rezeptoren führt zur Zytolyse der Epithelzellen. Dem MICA-Allel 5.1 fehlt ein C-terminales Sequenzfragment, das in räumlicher Nähe zur Transmembrandomäne ist. Die subzelluläre Lokalisation dieses für Zöliakiepatienten als klinisch protektiv beschriebene Allel ist unklar.

10.1055/s-0030-1263652

Cite

Citations (0)

Archives alluviales holocènes et occupation humaine en Basse Moulouya (Maroc nord-oriental) Holocene alluvial archives and human occupation in the Lower Moulouya River (north-eastern Morocco)

Hanoun Ibouhouten Christoph Zielhofer Rachida Mahjoubi Saı̈d Kamel Jörg Linstädter

The Lower Moulouya Basin in northeast Morocco is characterised by Mediterranean arid to semiarid environmental conditions of a North African desert margin. In geomorphological research, desert margins reveal a high potential for palaeoenvironmental studies, as they react very sensitive to past and future climatic changes. The alluvial deposits of the Lower Moulouya can be divided in three sedimentation series: the Series I is dated between 9.9 and 6.5 ka cal. BP and shows silty to sandy layers with hydromorphic features and intercalated initial alluvial soils. The Series II is dated between 4.2 and 3.2 ka cal. BP and indicates clayey to silty fine laminae with hydromorphic features and an onset of charcoal-rich layers. The Series III is dated between 3.2 and 1.4 ka cal. BP and features clayey to silty fine laminae with greyish to reddish colouring. Series III reveals charcoal-rich layers and gypsum crystals in clay-rich reddish sediments. The dating of the archaeological findings (silex, ceramics, bones) of the buried open air sites indicate an human occupation at the Lower Moulouya during the Epipalaeolithics, Neolithics, Protohistoric and Middle Ages. The phases correspond chronologically with already known archaeological archives from eastern Rif rock-shelters and caves. The maximum of archaeological findings at the Lower Moulouya corresponds to the Early Neolithics, a period which comes along with the Mid-Holocene climatic optimum.

Charcoal

Alluvial plain

Alluvial fan

Source

Cite

Citations (0)

Archives alluviales holocènes et occupation humaine en Basse Moulouya (Maroc nord-oriental)

Géomorphologie relief processus environnement (2010)

Hanoun Ibouhouten Christoph Zielhofer Rachida Mahjoubi Saı̈d Kamel Jörg Linstädter

Le bassin de la Basse Moulouya se situe dans le nord-est du Maroc, dans un environnement méditerranéen aride à semi-aride typique des marges des déserts nord-africains. Les recherches géomorphologiques sur les marges des déserts attestent un grand potentiel pour les études paléoenvironnementales car ces marges réagissent de manière très sensible aux changements climatiques passés et futurs. Les dépôts de la plaine d'inondation sont constitués par trois séries de dépôts sédimentaires : la série I datée entre 9,9 et 6,5 ka cal. BP, à faciès sablo-limoneux et hydromorphique avec intercalation de quelques paléosols alluviaux peu développés ; la série II, datée entre 4,4 et 3,2 ka cal. BP, caractérisée par un faciès limono-argileux très finement laminé et hydromorphique, avec l'apparition de quelques couches noirâtres riches en charbon de bois. La série III, datée entre 3,2 et 1,4 ka cal. BP, formée par l'alternance de couches centimétriques à litage horizontal de couleurs grisâtre et rougeâtre, de faciès à dominance limono-argileuse. Les couches argileuses rouges de la série III renferment du gypse et contiennent plusieurs couches riches en particules charbonneuses. La datation de certains foyers anthropiques dans les alluvions étudiées, riches en matériel archéologique (silex, céramique, ossements), révèle l'occupation temporaire du fond de vallée par l'Homme pendant l'Épipaléolithique, le Néolithique, la Protohistoire et le Moyen Age. Ces périodes d'occupation sont également visibles dans les grottes, dans les sites de plein air et dans les tumuli de l'arrière-pays de la Moulouya. Le maximum d'occupation est observé pendant le Néolithique ancien, période qui correspond à l'optimum climatique holocène.

10.4000/geomorphologie.7812

Cite

Citations (17)

Determination and Modulation of Total and Surface Calcium-Sensing Receptor Expression in Monocytes In Vivo and In Vitro

PLoS ONE (2013)

Julien Paccou Cédric Boudot Aurélien Mary Saı̈d Kamel Tilman B. Drüeke

Expression of the calcium-sensing receptor (CaSR) has previously been demonstrated in human circulating monocytes (HCM). The present study was designed to measure CaSR expression in HCM and to examine its potential modulation by pro-inflammatory cytokines, Ca2+, vitamin D sterols in U937 cell line. Twenty healthy volunteers underwent blood sampling with subsequent isolation of peripheral blood mononuclear cells (PBMC) at 3 visits. Flow cytometry analysis (FACS) was performed initially (V1) and 19 days later (V2) to examine intra- and intersubject fluctuations of total and surface CaSR expression in HCM and 15 weeks later (V3) to study the effect of vitamin D supplementation. In vitro experiments were conducted to assess the effects of pro-inflammatory cytokines, calcidiol, calcitriol and Ca2+ on CaSR expression in U937 cell line. By FACS analysis, more than 95% of HCM exhibited cell surface CaSR staining. In contrast, CaSR staining failed to detect surface CaSR expression in other PBMC. After cell permeabilization, total CaSR expression was observed in more than 95% of all types of PBMC. Both total and surface CaSR expression in HCM showed a high degree of intra-assay reproducibility (<3%) and a moderate intersubject fluctuation. In response to vitamin D supplementation, there was no significant change for both total and surface CaSR expression. In the in vitro study, U937 cells showed strong total and surface CaSR expression, and both were moderately increased in response to calcitriol exposure. Neither total nor surface CaSR expression was modified by increasing Ca2+ concentrations. Total CaSR expression was concentration dependently decreased by TNFα exposure. In conclusion, CaSR expression can be easily measured by flow cytometry in human circulating monocytes. In the in vitro study, total and surface CaSR expression in the U937 cell line were increased by calcitriol but total CaSR expression was decreased by TNFα stimulation.

Monocyte

Receptor expression

10.1371/journal.pone.0074800

Cite

Citations (9)