Background Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effects of XRCC1 variants on childhood ALL risk. Methods A meta-analysis was performed to examine the association between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and childhood ALL risk. We critically reviewed 7 studies with a total of 880 cases and 1311 controls for Arg399Gln polymorphism, 3 studies with a total of 345 cases and 554 controls for Arg280His polymorphism, and 6 studies with a total of 783 cases and 1180 controls for Arg194Trp polymorphism, respectively. Odds ratio (OR) and its 95% confidence interval (CI) were used. Results Significant association between XRCC1 Arg399Gln polymorphism and childhood ALL risk was observed in total population analyses (ORadditive model = 1.501, 95% CI 1.112–2.026, POR = 0.008; ORdominant model = 1.316, 95% CI = 1.104–1.569, POR = 0.002) and Asian subgroup analyses (ORadditive model = 2.338, 95%CI = 1.254–4.359, POR = 0.008; ORdominant model = 2.108, 95%CI = 1.498–2.967, POR = 0.000). No association was detected in Caucasians, Metizo and mixed populations. Ethnicity was considered as a significant source of heterogeneity in the meta-regression model. For the other two XRCC1 polymorphisms, no association with childhood ALL risk was found. Conclusions The meta-analysis results suggested that XRCC1 Arg399Gln polymorphism might be associated with elevated childhood ALL risk among Asian population.
Abstract The Weihe River Basin has the worst soil erosion in the Loess Plateau. As the largest tributary of the Yellow River, the water conservation capacity in the Weihe River Basin is of great significance to the Yellow River Basin and the Loess Plateau. In this study, the volume of the water conservation in the Weihe River Basin is estimated based on the Integrated Valuation of Ecosystem Services and Tradeoffs model, and the water conservation capacity of the basin is measured after excluding the influence of rainfall and evapotranspiration. The results show that from 1987 to 2019, the water conservation in the Weihe River Basin showed an overall trend of decreasing first and then increasing. The increasing trend of water conservation is greater than that of water production. The water conservation in the Weihe River Basin decreased to the lowest in 2005 and increased to the highest in 2019. Spatially, the water conservation volume is large in the south and west and small in the north and east. The water conservation volumes increase in the middle reaches of the Weihe River, the source of the Weihe River and the Jinghe River Basin. The overall capacity of the water yield and water conservation in the Weihe River Basin shows the same increasing trend. The projects of returning farms to forests and ecological management contribute to improving the water conservation capacity in the Weihe River Basin.
'/%3e%3cuse xlink:href='%23a' transform='rotate(23.036 .093 25.536)'/%3e%3cuse xlink:href='%23a' transform='rotate(45.87 1.273 16.18)'/%3e%3cuse xlink:href='%23a' transform='rotate(69.945 .996 12.078)'/%3e%3cuse xlink:href='%23a' transform='rotate(20.66 -19.689 31.932)'/%3e%3c/svg%3e)