Jialin Fan

Lishui City People's Hospital

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Chunlong Zhang

China University of Mining and Technology

Xin Gu

Beijing University of Chinese Medicine

Yuhan Gao

Queen's University Belfast

Lianchun Wang

Southwest Forestry University

Yi Lu

Nanjing Forestry University

Zhong Chen

Ministry of Agriculture and Rural Affairs

Chunyuan Zheng

Beijing Forestry University

Shenglin Liu

Aarhus University

Jian Wu

Huazhong Agricultural University

Qinfu Sun

Yangzhou University

Cooperative Institutions

Yangzhou University

Beijing Forestry University

Chinese Academy of Sciences

Ministry of Agriculture and Rural Affairs

Huazhong Agricultural University

Nanjing Medical University

Kunming University of Science and Technology

Chinese Academy of Agricultural Sciences

Fudan University

Harbin Medical University

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Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription

Scientific Reports (2016)

Hui Han Jialin Fan Yue Xiong Wenqing Wu Yi Lu

Abstract Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential to the same process. It has been reported that Ap and Chi function as a tetramer to regulate Notch signaling. At the same time, dLMO (the protein product of gene bx ) regulates the activity of Ap by competing its binding with Chi. However, the detailed functions of Chi and dLMO on Notch signaling and the relevant mechanisms remain largely unknown. Here, we report the detailed functions of Chi and dLMO on Notch signaling. Different Chi protein levels in adjacent cells could activate Notch signaling mainly in the cells with higher level of Chi. dLMO could induce antagonistical phenotypes on Notch signaling compared to that induced by Chi. These processes depend on their direct regulation of fringe ( fng ) transcription.

Hes3 signaling axis

Notch proteins

10.1038/srep18937

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Citations (4)

Natural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape

Nature Communications (2024)

Lin Li X.Q. Zhang Jialin Fan Jiawei Li Sichao Ren

Abstract Sclerotinia stem rot (SSR), caused by the necrotrophic fungus Sclerotinia sclerotiorum , is one of the most devastating diseases for several major oil-producing crops. Despite its impact, the genetic basis of SSR resistance in plants remains poorly understood. Here, through a genome-wide association study, we identify a key gene, BnaA07. MKK9 , that encodes a mitogen-activated protein kinase kinase that confers SSR resistance in oilseed rape. Our functional analyses reveal that BnaA07.MKK9 interacts with BnaC03.MPK3 and BnaC03.MPK6 and phosphorylates them at the TEY activation motif, triggering a signaling cascade that initiates biosynthesis of ethylene, camalexin, and indole glucosinolates, and promotes accumulation of H 2 O 2 and the hypersensitive response, ultimately conferring resistance. Furthermore, variations in the coding sequence of BnaA07.MKK9 alter its kinase activity and improve SSR resistance by ~30% in cultivars carrying the advantageous haplotype. These findings enhance our understanding of SSR resistance and may help engineer novel diversity for future breeding of oilseed rape.

Sclerotinia Sclerotiorum

Sclerotinia

Germ plasm

10.1038/s41467-024-49504-6

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Genomics and biodegradation properties of an oleophilic bacterium isolated from shale oil sludge

International Biodeterioration & Biodegradation (2025)

Shuang Deng Cichong Cai Junwei Wang Danping Qin Liyun Yu

10.1016/j.ibiod.2025.106028

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Indigenous arbuscular mycorrhizal fungi can alleviate salt stress and promote growth of cotton and maize in saline fields

Plant and Soil (2015)

Shenglin Liu Xiuli Guo Gu Feng Baidengsha Maimaitiaili Jialin Fan

Microcosm

10.1007/s11104-015-2656-5

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Citations (71)

Genome-Wide Identification, Characterization, and Expression Analysis of the CYP450 Family Associated with Triterpenoid Saponin in Soapberry (Sapindus mukorossi Gaertn.)

Forests (2024)

Chunyuan Zheng Mingzhu Zhou Jialin Fan Yuhan Gao Yuanyuan Xu

Soapberry (Sapindus mukorossi Gaertn.) is a tree species of the family Sapindaceae, the pericarp of which is rich in triterpenoid saponins, which are important in chemical production, biomedicine, and other fields. Cytochrome P450 monooxygenase (CYP450) is involved in the modification of the skeletons of triterpenoid saponins and is linked to their diversity. We previously identified 323 CYP450 genes in the transcriptome of soapberry and screened 40 CYP450 genes related to the synthesis of triterpenoid saponins by gene annotation and conserved structural domain analysis. The genetic structure and phylogeny of the CYP450 genes were analyzed separately. Phylogenetic analysis categorized the CYP450 genes of soapberry into five subfamilies, the members of which had similar conserved cumulative sequences and intron structures. A cis-acting element analysis implicated several genes in the responses to environmental changes and hormones. The expression of several genes during eight periods of fruit development was analyzed by real-time quantitative qRT-PCR; most showed high expression during the first four periods of fruit development, and their expression decreased as the fruits matured. A co-expression network analysis of SmCYP450s and related genes in the triterpenoid saponin synthesis pathway was performed. Correlation analysis showed that 40 SmCYP450s may be involved in saponin synthesis in soapberry. The triterpenoid saponin synthesis-related candidate genes identified in this study provide insight into the synthesis and regulation of triterpenoid saponins in soapberry.

Identification

Triterpenoid saponin

10.3390/f15060926

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