Xingyong Wan

Zhejiang University

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Chaohui Yu

First Affiliated Hospital Zhejiang University

Chengfu Xu

First Affiliated Hospital Zhejiang University

Youming Li

Zhejiang University

Youming Li

First Affiliated Hospital Zhejiang University

Hua-Tuo Zhu

First Affiliated Hospital Zhejiang University

Yiming Lin

Fifth Affiliated Hospital of Sun Yat-sen University

Chao Lü

Nanjing University of Chinese Medicine

Zhe Shen

First Affiliated Hospital Zhejiang University

Youming Li

Chinese Academy of Sciences

Lan Li

Sichuan University

Cooperative Institutions

Zhejiang University

First Affiliated Hospital Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Blood Center of Zhejiang Province

Sun Yat-sen University

Zhejiang Ocean University

Peking University

Shanghai Jiao Tong University

Zhejiang Chinese Medical University

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Caveolin1 protects against diet induced hepatic lipid accumulation in mice

PLoS ONE (2017)

Meng Li Dahua Chen Haixiu Huang Jiewei Wang Xingyong Wan

Caveolin1 (CAV1) is involved in lipid homeostasis and endocytosis, but little is known about the significance of CAV1 in the pathogenesis and development of nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the role of CAV1 in NAFLD.Expression of CAV1 in the in vitro and in vivo models of NAFLD was analyzed. The effects of CAV1 knockdown or overexpression on free fatty acid (FFA)-induced lipid accumulation in L02 cells and AML12 cells were determined. CAV1 knockout (CAV1-KO) mice and their wild-type (WT) littermates were subjected to a high fat diet (HFD) for 4 weeks, and the functional consequences of losing the CAV1 gene and its subsequent molecular mechanisms were also examined.Noticeably, CAV1 expression was markedly reduced in NAFLD. CAV1 knockdown led to the aggravation of steatosis that was induced by FFA in both L02 cells and AML12 cells, while CAV1 overexpression markedly attenuated lipid accumulation in the cells. Consistent with CAV1 repression in the livers of HFD-induced mice, the CAV1-KO mice exhibited more severe hepatic steatosis upon HFD intake. In addition, increased cholesterol levels and elevated transaminases were detected in the plasma of CAV1-KO mice. The protein expression of SREBP1, a key gene involved in lipogenesis, was augmented following CAV1 suppression in FFA-treated hepatocytes and in the livers of HFD-fed CAV1-KO mice.CAV1 serves as an important protective factor in the development of NAFLD by modulating lipid metabolism gene expression.

Steatosis

Lipogenesis

Knockout mouse

Lipid droplet

10.1371/journal.pone.0178748

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Citations (34)

Clinical guidelines of non-alcoholic fatty liver disease: A systematic review

World Journal of Gastroenterology (2016)

Jinzhou Zhu Kelseanna Hollis‐Hansen Xingyong Wan Sujuan Fei Xunlei Pang

AIMTo perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease (NAFLD). METHODSA database search was conducted on PubMed for guidelines published before May 2016, supplemented by reviewing relevant websites.The Appraisal of Guidelines for Research and Evaluation (ARGEE) instrument Ⅱ was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally.it was used to appraise the quality of guidelines in this study.The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key organizations. RESULTSEleven guidelines were included in this study.Since 2007, guidelines have been released in Asia (3 in China, 1 in South Korea, and 1 in Japan), Europe (1 in italy),

Guideline

10.3748/wjg.v22.i36.8226

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Citations (35)

Computational Prediction and Validation of BAHD1 as a Novel Molecule for UlcerativeColitis

Scientific Reports (2015)

Hua-Tuo Zhu Xingyong Wan Jing Li Lu Han Xiaochen Bo

Abstract Ulcerative colitis (UC) is a common inflammatory bowel disease (IBD) producingintestinal inflammation and tissue damage. The precise aetiology of UC remainsunknown. In this study, we applied a rank-based expression profile comparativealgorithm, gene set enrichment analysis (GSEA), to evaluate the expression profilesof UC patients and small interfering RNA (siRNA)-perturbed cells to predict proteinsthat might be essential in UC from publicly available expression profiles. We usedquantitative PCR (qPCR) to characterize the expression levels of those genespredicted to be the most important for UC in dextran sodium sulphate (DSS)-inducedcolitic mice. We found that bromo-adjacent homology domain (BAHD1), a novelheterochromatinization factor in vertebrates, was the most downregulated gene. Wefurther validated a potential role of BAHD1 as a regulatory factor for inflammationthrough the TNF signalling pathway in vitro . Our findings indicate thatcomputational approaches leveraging public gene expression data can be used to inferpotential genes or proteins for diseases and BAHD1 might act as an indispensablefactor in regulating the cellular inflammatory response in UC.

10.1038/srep12227

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Citations (18)

Intestinal ulcers in a patient with myelodysplastic syndrome: a case report

BMC Gastroenterology (2021)

Xiaofen Zhang Meng Jin Zhe Shen Xingyong Wan Lan Li

Abstract Background Trisomy 8 positivity myelodysplastic syndrome with Behçet's disease is rare. Isolated trisomy 8 is a frequent cytogenetic abnormality in the MDS, but the characteristic of trisomy 8 and the association between trisomy 8 positivity myelodysplastic syndrome and Behçet's disease is unclear. Case presentation Here, we reported a 63‐year‐old man, who presented with fever, abdominal pain and hematochezia. Imaging studies revealed bowel wall thickening and mural hyperenhancement of terminal ileum and cecum. Colonoscopy found multiple round ulcers in terminal ileum, ileocecal valve and multiple yellow dotted pseudomembranous attachments throughout the colon. Capsule endoscopy also revealed multiple irregular ulcers in lower ileum. Serum C-reactive protein levels and fecal calprotectin were abnormally high. The clostridium difficile toxin A and B was positive. However, the patient's intestinal ulcers did not resolve after two weeks course of vancomycin. Considered that the patient was diagnosed as MDS-RAEB2 with a karyotype of 47 XX, + 8. And detailed inquiry of medical history revealed epifolliculitis and frequently recurrent oral ulcers 2 months before admission. A diagnosis of trisomy 8 positivity MDS with BD was made. Then he received glucocorticoid along with the 5th course of azacytidine. The follow-up endoscopy showed significantly improved intestinal ulcer 2 months after treatment. we report a rare disease and provide the diagnose and treatment ideas. Conclusions We highlight the challenges and the process of thinking about of the diagnosis. This may provide a new idea for the diagnosis of intestinal ulcers.

Trisomy 8

Ileocecal valve

Ileitis

Hematochezia

10.1186/s12876-021-01932-0

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Citations (1)

Su1795 Uric Acid Regulates Hepatic Steatosis and Insulin Resistance Through the NLRP3 Inflammasome Dependent Mechanism

Gastroenterology (2015)

Xingyong Wan Chengfu Xu Chao Lü Hua-Tuo Zhu Chaohui Yu

Tolerability

Simeprevir

Hepatitis C

Sofosbuvir

Clinical endpoint

Steatosis

10.1016/s0016-5085(15)33592-7

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Citations (2)

Sa2050 Screening for Pancreatic Cancer in Familial High-Risk Individuals: A Systematic Review

Gastroenterology (2015)

Chao Lü Chengfu Xu Xingyong Wan Chaohui Yu Youming Li

10.1016/s0016-5085(15)31324-x

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Citations (0)

Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis

Scientific Reports (2016)

Chao Lü Jianzhong Sang Haijian He Xingyong Wan Yiming Lin

Abstract This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve H. pylori eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of H. pylori infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of H. pylori infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone ( P = 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of H. pylori infection compared to the placebo.

10.1038/srep23522

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Citations (93)

Mo1543 Inhibition of MPST Prevents Hepatic Steatosis Through Hydrogen Sulfide-Dependent Mechanism

Gastroenterology (2016)

Meng Li Chengfu Xu Xingyong Wan Jianguo Gao Chaohui Yu

Steatosis

10.1016/s0016-5085(16)33847-1

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Citations (0)

Su1796 Xanthine Oxidase Promotes Hyperuricemia and Nonalcoholic Fatty Liver Disease in Patients and Mice

Gastroenterology (2015)

Chengfu Xu Xingyong Wan Lei Xu Min Miao Youming Li

10.1016/s0016-5085(15)33593-9

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Citations (1)

Detection of Gas Leaks from Sea Bed Using A Small Circular Array

OCEANS 2019 - Marseille (2019)

Mingjun Feng S.H. Huang T. C. Yang Qingying Tu Xingyong Wan

In this paper a small circular array of diameter ~ 15cm, with six elements, is used to detect the gas leaks from sea bed around the bore hole. Signal echo from different bearings will be extracted using beamforming technology. Such an array has a wide beam width and high sidelobe levels using conventional beamforming (CBF) which degrades the performance of beamforming results. In this paper, we use a superdirective beamforming technology which provides high resolution in bearing estimation with high array gain as well as strong interference rejection capability compared with CBF. This paper presents experiment results in an anechoic tank to locate the bearing of gas seeps.

Anechoic chamber

SIGNAL (programming language)

Circular buffer

Sensor array

10.1109/oceanse.2019.8867220

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Citations (3)