María J. Ruiz-de-León

Instituto Cajal

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Santiago Moreno

Hospital Universitario Ramón y Cajal

Esther Vázquez

Centro de Investigación Biomédica en Red

Francesc Vidal

Hospital Universitari Joan XXIII de Tarragona

Julià Blanco

IrsiCaixa

Manuel Leal

Hospital San Juan de la Cruz

Francisco J. Hernández-Walias

Instituto Cajal

Alejandro Vallejo

John H. Stroger, Jr. Hospital of Cook County

Yolanda M. Pacheco

Universidad Loyola Andalucía

Isaac Rosado‐Sánchez

Instituto de Biomedicina de Sevilla

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Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Instituto Cajal

Universitat Autònoma de Barcelona

Hospital Universitario Virgen del Rocío

Universidad de Sevilla

Instituto de Biomedicina de Sevilla

Consejo Superior de Investigaciones Científicas

Hospital Universitario Ramón y Cajal

Instituto Ramón y Cajal de Investigación Sanitaria

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New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144

Scientific Reports (2020)

Francisco J. Hernández-Walias María J. Ruiz-de-León Isaac Rosado‐Sánchez Esther Vázquez Manuel Leal

Abstract Up to 40% of newly diagnosed cases of HIV-1 infection are late diagnoses, with a profound decrease in CD4 cell counts in many cases. One-third of these individuals do not achieve optimal CD4 cell recovery (OR) after suppressive antiretroviral treatment (ART). This retrospective/longitudinal study of poor recovery (PR) included 79 HIV-1-infected individuals with CD4 count <200 cells/mm 3 (25 PR and 54 OR) before ART. After suppressive ART, 21 PR and 24 OR individuals were further analysed, including paired samples. Selected miRs and plasma inflammatory markers were determined to investigate their potential predictive/diagnostic value for poor recovery. miR-192, IL-6 and sCD14 were independently associated with CD4 recovery before ART (p = 0.031, p = 0.007, and p = 0.008, respectively). The combination of these three factors returned a good discrimination (predictive value for PR) value of 0.841 (AUC, p < 0.001). After suppressive ART, miR-144 was independently associated with CD4 recovery (p = 0.017), showing a moderate discrimination value of 0.730 (AUC, p = 0.008) for PR. Our study provides new evidence on the relationship between miRs and HIV-1 infection that could help improve the management of individuals at HIV-1 diagnosis. These miRs and cytokines signature sets provide novel tools to predict CD4 cell recovery and its progression after ART.

Cd4 t cell

10.1038/s41598-020-60073-8

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Citations (23)