Jiawei Li

Huazhong Agricultural University

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Xin Gu

Beijing University of Chinese Medicine

Jialin Fan

Lishui City People's Hospital

Jian Wu

Huazhong Agricultural University

Qinfu Sun

Yangzhou University

Sichao Ren

Yangzhou University

Lin Li

Yangzhou University

Panpan Li

Shandong Academy of Agricultural Sciences

Dongxiao Liu

Yangzhou University

Jingyi Xu

Yangzhou University

X.Q. Zhang

Yangzhou University

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Yangzhou University

Huazhong Agricultural University

Chinese Academy of Agricultural Sciences

Nanjing Medical University

Shandong Academy of Agricultural Sciences

Institute of Plant Protection

Ministry of Agriculture and Rural Affairs

Shanghai Zhangjiang Laboratory

Beijing University of Chinese Medicine

Beijing Hospital

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Natural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape

Nature Communications (2024)

Lin Li X.Q. Zhang Jialin Fan Jiawei Li Sichao Ren

Abstract Sclerotinia stem rot (SSR), caused by the necrotrophic fungus Sclerotinia sclerotiorum , is one of the most devastating diseases for several major oil-producing crops. Despite its impact, the genetic basis of SSR resistance in plants remains poorly understood. Here, through a genome-wide association study, we identify a key gene, BnaA07. MKK9 , that encodes a mitogen-activated protein kinase kinase that confers SSR resistance in oilseed rape. Our functional analyses reveal that BnaA07.MKK9 interacts with BnaC03.MPK3 and BnaC03.MPK6 and phosphorylates them at the TEY activation motif, triggering a signaling cascade that initiates biosynthesis of ethylene, camalexin, and indole glucosinolates, and promotes accumulation of H 2 O 2 and the hypersensitive response, ultimately conferring resistance. Furthermore, variations in the coding sequence of BnaA07.MKK9 alter its kinase activity and improve SSR resistance by ~30% in cultivars carrying the advantageous haplotype. These findings enhance our understanding of SSR resistance and may help engineer novel diversity for future breeding of oilseed rape.

Sclerotinia Sclerotiorum

Sclerotinia

Germ plasm

10.1038/s41467-024-49504-6

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