Daniel J. Daugherty

Texas Parks and Wildlife Department

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Wenbin Deng

Sun Yat-sen University

David A. Weber

Jennifer Jensen

Texas State University

Elena N. Dedkova

University of California, Davis

Xiyuan Lu

State Key Laboratory of Oncogene and Related Genes

Saul Schaefer

UC Davis Health System

Bert J. Frederich

University of California, Davis

Trent M. Sutton

University of Alaska Fairbanks

Herb Rodriguez

Universidade de Santiago de Compostela

Donald M. Bers

University of California, Davis

Cooperative Institutions

University of California, Davis

Texas State University

Shriners Hospitals for Children - Erie

UC Davis Health System

University of California Davis Medical Center

Loyola University Chicago

VA Northern California Health Care System

University of Queensland

University of California, San Francisco

Texas Parks and Wildlife Department

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Archaeological Reconnaissance of Nine in Situ Oil Shale Lease Tracts, Colorado-Utah

David A. Weber Kevin T. Jones Herb Rodriguez Corielle Jennings Daniel J. Daugherty

Lease

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Applying Floodplain Inundation Modeling to Estimate Suitable Spawning Habitat and Recruitment Success for Alligator Gar in the Guadalupe River, Texas

Hydrology (2023)

Kimberly M. Meitzen Clinton R. Robertson Jennifer Jensen Daniel J. Daugherty Thomas B. Hardy

We developed a floodplain inundation model to extract specific flood extent and depth parameters and combined these with vegetation land cover and historic flow data to quantify spatial habitat suitability and temporal hydrologic metrics that support Alligator Gar Atractosteus spatula spawning within a 257 km segment of the lower Guadalupe River, Texas, USA. We modeled nine flows across a range of flood frequency recurrence intervals from 257 m3s−1 to ~4997 m3s−1 and estimated the availability of suitable spawning water depths (0.2 to 2 m) and lateral connectedness between the river and suitable floodplain landcover types. We estimated the ages via otoliths of 95 Alligator Gar collected in the reach to determine the year that they were recruited into the system. We analyzed a total of 30 Indicators of Hydrologic Alteration flow metrics to examine how the spatially derived suitable habitats related to the temporal aspects of flow occurrence during the spawning season for the period of flow record April–July (1935–2020) and to the years spanning the recruitment data of the Alligator Gar (1981–2010). A non-linear relationship existed between suitable spawning habitat area and the flow regime, with the most habitat availability corresponding to the 10–20-year flood recurrence interval frequency with peak flows of 2057–3108 m3s−1, respectively. The Alligator Gar recruitment data indicated that six years provided high recruitment, which correlated with peak flows of ~5-year frequency with an available spawning area of ~9000 Ha, moderate recruitment years related to peak flows with ~3-year frequency with an available spawning area of 6000 Ha, and low recruitment years where spawning was likely to occur at least every other year with at least 2500 Ha of available spawning area. The results of this model support the development of legislatively mandated environmental flow standards for the Guadalupe River Basin, inform field-based efforts for collecting empirical and observational data on the species’ reproduction, and provide spatial and temporal information for designing conservation strategies for Alligator Gar.

10.3390/hydrology10060123

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The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis

Scientific Reports (2016)

Daniel J. Daugherty Olga Chechneva Florian Mayrhofer Wenbin Deng

Abstract The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS). To fundamentally elucidate the functions of TSPO, we first developed a viable TSPO knockout mouse. A conditional TSPO knockout mouse was generated by utilizing the Cre-Lox system. We generated a TSPO floxed mouse and then crossed this mouse with a Cre recombinase expressing mouse driven by the human glial fibrillary acidic protein (hGFAP) promoter. The resultant mouse was a neural linage line specific TSPO knockout. The loss of TSPO in the CNS did not result in overt developmental defects or phenotypes. The TSPO−/− mouse showed a decrease in GFAP expression, correlating with a decrease in astrogliosis in response to neural injury during EAE. This decrease in astrogliosis was also witnessed in the lessening of severity of EAE clinical scoring, indicating an in vivo functional role for TSPO in suppressing EAE. The TSPO−/− mouse could be a useful tool in better understanding the role of TSPO in CNS disease and our results implicate TSPO as a potential therapeutic target in MS.

Translocator protein

Astrogliosis

Knockout mouse

Conditional gene knockout

Encephalomyelitis

10.1038/srep22556

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Potential for reintroduction of lake sturgeon in five northern Lake Michigan tributaries: a habitat suitability perspective

Aquatic Conservation Marine and Freshwater Ecosystems (2007)

Daniel J. Daugherty Trent M. Sutton Robert F. Elliott

1. Conservation and rehabilitation efforts for lake sturgeon Acipenser fulvescens throughout the Great Lakes include the re-establishment of self-sustaining stocks in systems where they have been extirpated. 2. Information on the suitability of potential lake sturgeon habitat in tributaries is important for determining their capacity to support lake sturgeon stocking and to develop system-specific rehabilitation strategies. 3. Geo-referenced habitat information characterizing substrate composition, water depth, and stream gradient were applied to a life-stage specific lake sturgeon habitat suitability index in a geographic information system to produce spatially explicit models of life-stage specific habitat characteristics in five northern Lake Michigan tributaries from which lake sturgeon have been extirpated. 4. Habitat models indicated that high quality lake sturgeon spawning and staging habitat comprised 0 to 23% and 0 to 9% of the available habitat, respectively, whereas high quality juvenile lake sturgeon habitat was relatively ubiquitous throughout each river and comprised 39 to 99%. 5. Comparison of these data to lake sturgeon habitat availability in Lake Michigan tributaries currently supporting populations indicated that spawning and staging habitats may limit the ability of these systems to support spawning. Efforts to re-establish lake sturgeon populations in these systems should consider the creation of spawning and staging habitat to increase reproductive and recruitment potential prior to the initiation of stocking efforts. Copyright © 2007 John Wiley & Sons, Ltd.

Lake sturgeon

10.1002/aqc.878

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Citations (11)

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

Scientific Reports (2018)

Phung N. Thai Daniel J. Daugherty Bert J. Frederich Xiyuan Lu Wenbin Deng

Abstract Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca 2+ ) handling, energy failure and impaired mitophagy resulting in contractile dysfunction and myocyte death. We have previously shown that the 18-kDa mitochondrial translocator protein of the outer mitochondrial membrane (TSPO) can modulate mitochondrial Ca 2+ uptake. Experiments were designed to test the role of the TSPO in a murine pressure-overload model of HF induced by transverse aortic constriction (TAC). Conditional, cardiac-specific TSPO knockout (KO) mice were generated using the Cre- lox P system. TSPO-KO and wild-type (WT) mice underwent TAC for 8 weeks. TAC-induced HF significantly increased TSPO expression in WT mice, associated with a marked reduction in systolic function, mitochondrial Ca 2+ uptake, complex I activity and energetics. In contrast, TSPO-KO mice undergoing TAC had preserved ejection fraction, and exhibited fewer clinical signs of HF and fibrosis. Mitochondrial Ca 2+ uptake and energetics were restored in TSPO KO mice, associated with decreased ROS, improved complex I activity and preserved mitophagy. Thus, HF increases TSPO expression, while preventing this increase limits the progression of HF, preserves ATP production and decreases oxidative stress, thereby preventing metabolic failure. These findings suggest that pharmacological interventions directed at TSPO may provide novel therapeutics to prevent or treat HF.

Translocator protein

Pressure overload

Conditional gene knockout

Knockout mouse

10.1038/s41598-018-34451-2

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Citations (41)