Mengshu Xu

Jiangnan University

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Piaoping Yang

Harbin Engineering University

Huiting Bi

Wuhan Textile University

Jiating Xu

Northeast Forestry University

Dan Yang

Harbin Engineering University

Ruoxi Zhao

Harbin Engineering University

Qianqian Sun

Shandong University

Lili Feng

Harbin Engineering University

Shili Gai

Harbin Engineering University

Guixin Yang

Harbin University of Science and Technology

Fei He

Hainan Medical University

Cooperative Institutions

University of Toronto

Harbin Engineering University

Harbin University

Chinese Academy of Sciences

Changchun Institute of Applied Chemistry

University of California, San Francisco

Material Sciences (United States)

Howard Hughes Medical Institute

UCSF Helen Diller Family Comprehensive Cancer Center

Harvard University

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An intelligent nanoplatform for imaging-guided photodynamic/photothermal/chemo-therapy based on upconversion nanoparticles and CuS integrated black phosphorus

Chemical Engineering Journal (2019)

Mengshu Xu Guixin Yang Huiting Bi Jiating Xu Shuming Dong

Photon Upconversion

Black Phosphorus

Photothermal effect

10.1016/j.cej.2019.122822

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Citations (58)

Mitochondrial control through nutritionally regulated global histone H3 lysine-4 demethylation

Scientific Reports (2016)

M. Soloveychik Mengshu Xu Olga Zaslaver Kwanyin Lee Ashrut Narula

Abstract Histone demethylation by Jumonji-family proteins is coupled with the decarboxylation of α-ketoglutarate (αKG) to yield succinate, prompting hypotheses that their activities are responsive to levels of these metabolites in the cell. Consistent with this paradigm we show here that the Saccharomyces cerevisiae Jumonji demethylase Jhd2 opposes the accumulation of H3K4me3 in fermenting cells only when they are nutritionally manipulated to contain an elevated αKG/succinate ratio. We also find that Jhd2 opposes H3K4me3 in respiratory cells that do not exhibit such an elevated αKG/succinate ratio. While jhd2∆ caused only limited gene expression defects in fermenting cells, transcript profiling and physiological measurements show that JHD2 restricts mitochondrial respiratory capacity in cells grown in non-fermentable carbon in an H3K4me-dependent manner. In association with these phenotypes, we find that JHD2 limits yeast proliferative capacity under physiologically challenging conditions as measured by both replicative lifespan and colony growth on non-fermentable carbon. JHD2 ’s impact on nutrient response may reflect an ancestral role of its gene family in mediating mitochondrial regulation.

H3K4me3

Demethylation

Demethylase

Histone Methylation

10.1038/srep37942

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Citations (14)

Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake

Proceedings of the National Academy of Sciences (2015)

Ryan K. Schott Johannes Müller Clement G.Y. Yang Nihar Bhattacharyya Natalie P. H. Chan

Significance This study provides compelling evidence that the previously reported all-cone retina of a diurnal garter snake in fact contains a population of rod photoreceptors with the appearance, and presumably function, of cones. Our results suggest that the evolution of all-cone retinas occurred not through loss of rods but rather via the evolutionary transmutation of ancestral rods into more “cone-like” photoreceptors, to regain functionality that was lost during the early, possibly fossorial, origin of snakes. This study provides a better understanding of the process by which complex molecular/cellular structures and tissue types can evolve, and how, particularly for sensory systems, physiological constraints can be shaped by selective forces to produce evolutionary novelty.

Transducin

Opsin

Crepuscular

Visual phototransduction

10.1073/pnas.1513284113

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Citations (77)

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

Science (2018)

Julien Ablain Mengshu Xu Harriet Rothschild Richard C. Jordan Jeffrey K. Mito

Hunting and fishing for cancer genes Mucosal melanoma is a rare, but deadly, form of melanoma that occurs in sun-protected tissues. Little is known about the genetic alterations that drive the growth of these tumors. Ablain et al. sequenced mucosal melanomas from 43 patients and found that a substantial fraction showed inactivation or loss of SPRED1 , a gene that encodes a negative regulator of RAS–MAPK (mitogen-activated protein kinase) signaling. Using a platform called MAZERATI (Modeling Approach in Zebrafish for Rapid Tumor Initiation), they discovered that SPRED1 loss may help explain the poor response of melanoma patients to drugs that inhibit the KIT tyrosine kinase. The results suggest that a combination of KIT inhibitors and drugs that inhibit MAPK signaling may be more effective. Science , this issue p. 1055

Mucosal melanoma

10.1126/science.aau6509

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Citations (130)

Combination of CuS and g-C3N4 QDs on upconversion nanoparticles for targeted photothermal and photodynamic cancer therapy

Chemical Engineering Journal (2018)

Mengshu Xu Guixin Yang Huiting Bi Jiating Xu Lili Feng

Biocompatibility

Photon Upconversion

Nanomaterials

Photothermal effect

10.1016/j.cej.2018.12.052