E. V. Gavrilova

State Research Center of Virology and Biotechnology VECTOR

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Alexey V. Danilenko

State Research Center of Virology and Biotechnology VECTOR

RА

Rinat А. Maksyutov

State Research Center of Virology and Biotechnology VECTOR

Ivan M. Susloparov

State Research Center of Virology and Biotechnology VECTOR

V. Yu. Marchenko

State Research Center of Virology and Biotechnology VECTOR

Svetlana V. Svyatchenko

State Research Center of Virology and Biotechnology VECTOR

Alexander B. Ryzhikov

State Research Center of Virology and Biotechnology VECTOR

Natalia Kolosova

State Research Center of Virology and Biotechnology VECTOR

ТВ

Т. В. Трегубчак

State Research Center of Virology and Biotechnology VECTOR

Julia A. Bulanovich

State Research Center of Virology and Biotechnology VECTOR

АГ

А. Г. Дурыманов

State Research Center of Virology and Biotechnology VECTOR

Cooperative Institutions

State Research Center of Virology and Biotechnology VECTOR

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Siberian Federal University

AgroBio

Novosibirsk State University

Russian Academy of Sciences

Genetic Technologies (Australia)

Vector (United States)

Ministry of Health of the Russian Federation

Vietnamese - German Center of Excellence in Medical Research

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The Construction of the Mineral Component Model of the Bazhenov Suite as the Basis for the Further Creation of the Petrophysical Model

A. A. Astaf'ev D.V. Fedorova V.M. Yatsenko E. V. Gavrilova А. П. Новиков

Summary On the example of several wells in the north of Western Siberia the features of the spatial distribution of Bazhenov Formation productive reservoirs deposits was described. For Bazhenov Formation was determined lithological, petrophysical and geochemical methods of research. The results obtained mineral-component composition of deposits Bazhenov formation on the core and restored by GIS using the construction of bulk mineral component model, identified potentially productive intervals in the context of pyrolytic studies and brittleness.

Petrophysics

Mineral resource classification

Component (thermodynamics)

Brittleness

10.3997/2214-4609.201900474

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Quantitative Assessment of Airborne Transmission of Human and Animal Influenza Viruses in the Ferret Model

Atmosphere (2023)

Andrei S. Gudymo G. S. Onkhonova Alexey V. Danilenko Ivan M. Susloparov Natalia V. Danilchenko

The WHO has developed a tool to assess the risk of newly emerging influenza viruses with pandemic potential (TIPRA). According to TIPRA, the main parameters for assessing the risk of human-to-human transmission of a novel influenza virus are its ability to bind to human cell receptors of the upper respiratory tract (URT) and transmit in model animals. The aim of this study was to quantify airborne transmission of human and animal influenza viruses in the ferret model. The transmission of influenza viruses was studied in the ferret model in an aerobiology chamber. Airborne particles concentration and fractional composition in the aerobiology chamber were measured using an aerosol particle counter and analytical aerosol filters. Viral load in ferret nasal washings and aerosol filters was determined by titration in MDCK cells and quantitative RT-PCR. Genetic analysis of influenza viruses was performed using virus genome sequences obtained by NGS. After intranasal infection, human and animal influenza viruses replicated in the cells of nasal mucosa in ferrets. The level of virus airborne particles contamination provided by infected animals depends on the infectious dose and differs significantly between influenza virus strains. The studied avian influenza viruses show insufficient transmission in the ferret model, while human and swine influenza viruses are highly transmitted in ferrets. We propose a quantitative model of airborne transmission of influenza virus from donor to recipient ferrets. Level of influenza virus transmission in the ferret model correlates with genetic markers of virus receptor specificity and the level of virus airborne particle contamination induced by donor ferrets.

Airborne Transmission

Aerobiology

10.3390/atmos14030471

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Correction: Severe cases of seasonal influenza in Russia in 2017-2018

PLoS ONE (2019)

Natalia Kolosova T. N. Ilyicheva Alexey V. Danilenko Julia A. Bulanovich Svetlana V. Svyatchenko

Rows 92-96 of the Virus column in S6 Table are incorrect.Please view the correct S6 Table below.

Correct name

Seasonal influenza

10.1371/journal.pone.0227382

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Severe cases of seasonal influenza in Russia in 2017-2018

PLoS ONE (2019)

Natalia Kolosova T. N. Ilyicheva Alexey V. Danilenko Julia A. Bulanovich Svetlana V. Svyatchenko

The 2017-2018 influenza epidemic season in Russia was characterized by a relatively low morbidity and mortality. We evaluated herd immunity prior to the 2017-2018 influenza season in hemagglutination inhibition assay, and performed characterization of influenza viruses isolated from severe or fatal influenza cases and from influenza cases in people vaccinated in the fall of 2017. During the 2017-2018 epidemic season, 87 influenza A and B viruses were isolated and viruses of the 75 influenza cases, including selected viral isolates and viruses analyzed directly from the original clinical material, were genetically characterized. The analyzed A(H1N1)pdm09 viruses belonged to clade 6B.1, B/Yamagata-like viruses belonged to clade 3, and B/Victoria-like viruses belonged to clade 1A and they were antigenically similar to the corresponding vaccine strains. A(H3N2) viruses belonged to clade 3C.2a and were difficult to characterize antigenically and the analysis indicated antigenic differences from the corresponding egg-grown vaccine strain. The next generation sequencing revealed the presence of D222/G/N polymorphism in the hemagglutinin gene in 32% of the analyzed A(H1N1)pdm09 lethal cases. This study demonstrated the importance of monitoring D222G/N polymorphism, including detection of minor viral variants with the mutations, in the hemagglutinin gene of A(H1N1)pdm09 for epidemiological surveillance. One strain of influenza virus A(H1N1)pdm09 was resistant to oseltamivir and had the H275Y amino acid substitution in the NA protein. All other isolates were susceptible to NA inhibitors. Prior to the 2017-2018 epidemic season, 67.4 million people were vaccinated, which accounted for 46.6% of the country's population. Just before the epidemic season 33-47% and 24-30% of blood sera samples collected within the territory of Russia showed the presence of protective antibody titers against vaccine strains of influenza A and influenza B/Victoria-like, respectively. Mass vaccination of the population had evidently reduced the severity of the flu epidemic during the 2017-2018 influenza epidemic season in Russia.

Hemagglutination assay

H5N1 genetic structure

Oseltamivir

Herd Immunity

10.1371/journal.pone.0220401

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Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018–2019

PLoS ONE (2021)

Alexey V. Danilenko Natalia Kolosova Аlexander N. Shvalov T. N. Ilyicheva Svetlana V. Svyatchenko

Outbreaks of influenza, which is a contagious respiratory disease, occur throughout the world annually, affecting millions of people with many fatal cases. The D222G/N mutations in the hemagglutinin (HA) gene of A(H1N1)pdm09 are associated with severe and fatal human influenza cases. These mutations lead to increased virus replication in the lower respiratory tract (LRT) and may result in life-threatening pneumonia. Targeted NGS analysis revealed the presence of mutations in major and minor variants in 57% of fatal cases, with the proportion of viral variants with mutations varying from 1% to 98% in each individual sample in the epidemic season 2018–2019 in Russia. Co-occurrence of the mutations D222G and D222N was detected in a substantial number of the studied fatal cases (41%). The D222G/N mutations were detected at a low frequency (less than 1%) in the rest of the studied samples from fatal and nonfatal cases of influenza. The presence of HA D222Y/V/A mutations was detected in a few fatal cases. The high rate of occurrence of HA D222G/N mutations in A(H1N1)pdm09 viruses, their increased ability to replicate in the LRT and their association with fatal outcomes points to the importance of monitoring the mutations in circulating A(H1N1)pdm09 viruses for the evaluation of their epidemiological significance and for the consideration of disease prevention and treatment options.

10.1371/journal.pone.0251019

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Citations (7)