Ya-Chi Chan

Boston Children's Museum

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Che Lin

Taipei Medical University-Shuang Ho Hospital

Yu–Fen Wang

National Taiwan University Hospital

Dar‐Ren Chen

Changhua Christian Hospital

Kuo-Juei Lin

E-Da Hospital

Lisheng Lin

Putian University

Yuanting Yang

Wuhan University

Po-Hsiung Lin

National Chung Hsing University

Hui‐Ju Yang

Changhua Christian Hospital

Wei-Chung Hsieh

Heidelberg University

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Changhua Christian Hospital

National Chung Hsing University

Huazhong University of Science and Technology

Chung Shan Medical University

Weatherford College

Taipei Medical University

Taipei Medical University-Shuang Ho Hospital

National Cheng Kung University

Kaohsiung Medical University

Chung Hwa University of Medical Technology

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Albumin and hemoglobin adducts of estrogen quinone as biomarkers for early detection of breast cancer

PLoS ONE (2018)

Po-Hsiung Lin Hui‐Ju Yang Wei-Chung Hsieh Che Lin Ya-Chi Chan

Cumulative estrogen concentration is an important determinant of the risk of developing breast cancer. Estrogen carcinogenesis is attributed to the combination of receptor-driven mitogenesis and DNA damage induced by quinonoid metabolites of estrogen. The present study was focused on developing an improved breast cancer prediction model using estrogen quinone-protein adduct concentrations. Blood samples from 152 breast cancer patients and 71 healthy women were collected, and albumin (Alb) and hemoglobin (Hb) adducts of estrogen-3,4-quinone and estrogen-2,3-quinone were extracted and evaluated as potential biomarkers of breast cancer. A multilayer perceptron (MLP) was used as the predictor model and the resultant prediction of breast cancer was more accurate than other existing detection methods. A MLP using the logarithm of the concentrations of the estrogen quinone-derived adducts (four input nodes, 10 hidden nodes, and one output node) was used to predict breast cancer risk with accuracy close to 100% and area under curve (AUC) close to one. The AUC value of one showed that both data sets were separable. We conclude that Alb and Hb adducts of estrogen quinones are promising biomarkers for the early detection of breast cancer.

10.1371/journal.pone.0201241

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