Haiyun Jiang

Shanghai Ocean University

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L CAO

Shanghai Ocean University

Feiyang Zhou

Central South University

Qiang Liu

Shanghai Ocean University

Hongguang Tang

Shanghai Ocean University

Xuehong Dong

Shanghai Ocean University

Xinxin Zhang

Huazhong University of Science and Technology

Chengguo Hu

Wuhan University

Jinyang Shen

Shanghai Ocean University

Kunming Qin

Shanghai Ocean University

Yue Zhou

Hunan University of Traditional Chinese Medicine

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Shanghai Ocean University

Huazhong University of Science and Technology

Central South University

Harbin Institute of Technology

Zhejiang University

Huashan Hospital

Fudan University

Donghua University

Chinese Academy of Sciences

Jiangsu Yanjiang Chemical Resources Development Research Institute (China)

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Exploring the mechanisms of chronic obstructive pulmonary disease and Crohn’s disease: a bioinformatics-based study

Scientific Reports (2024)

Xinxin Zhang Caiping Liu L CAO Hongguang Tang Haiyun Jiang

This study explored the comorbid mechanisms between Crohn's disease (CD) and chronic obstructive pulmonary disease (COPD) using bioinformatics analysis. From the Gene Expression Omnibus (GEO) microarray dataset, 349 common differentially expressed genes (coDEGs) were identified, and 8 shared hub genes were found: CCL2, CXCL1, TLR2, ICAM1, PTPRC, ITGAX, PTGS2, and MMP9, which were vital for immune function and regulation of inflammatory responses. In addition, the study also analyzed the association between coDEGs and immune cell infiltration using the single-sample gene set enrichment algorithm (ssGSEA). Potential drugs related to these genes were identified using the connectivity map (CMap). These findings provided new perspectives for understanding the interaction between CD and COPD.

CXCL1

Immune Dysregulation

10.1038/s41598-024-78697-5

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