Liu Shi

University of Oxford

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Ellen V. Backhouse

University of Edinburgh

Mathew A. Harris

NHS Lothian

David J. Porteous

Western General Hospital

Andrew M. McIntosh

University of Edinburgh

Xueyi Shen

University of Edinburgh

Claire Green

University of Edinburgh

Ting Shi

First Affiliated Hospital Zhejiang University

Rosie M. Walker

University of Edinburgh

Tamir Chandra

Mayo Clinic in Arizona

Joanna M. Wardlaw

University of Edinburgh

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University of Edinburgh

Edinburgh Cancer Research

Western General Hospital

Royal Edinburgh Hospital

MRC Institute of Genetics and Molecular Medicine

University of Glasgow

UK Dementia Research Institute

NHS Lothian

University of Oslo

The Queen's Medical Research Institute

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Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Nature Communications (2022)

Danni A. Gadd Robert F. Hillary Daniel L. McCartney Liu Shi Aleks Stolicyn

Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, we report an integrated DNA methylation and phenotypic study of the circulating proteome in relation to brain health. Methylome-wide association studies of 4058 plasma proteins are performed (N = 774), identifying 2928 CpG-protein associations after adjustment for multiple testing. These are independent of known genetic protein quantitative trait loci (pQTLs) and common lifestyle effects. Phenome-wide association studies of each protein are then performed in relation to 15 neurological traits (N = 1,065), identifying 405 associations between the levels of 191 proteins and cognitive scores, brain imaging measures or APOE e4 status. We uncover 35 previously unreported DNA methylation signatures for 17 protein markers of brain health. The epigenetic and proteomic markers we identify are pertinent to understanding and stratifying brain health.

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Proteome

10.1038/s41467-022-32319-8

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Duodenal bleeding as a rare presenting symptom of haemorrhagic fever with renal syndrome

European Journal of Gastroenterology & Hepatology (2019)

Liu Shi Ting Shi Ya Zhao Jian Gong

Department of Gastroenterology, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, P.R. China Received 17 July 2019 Accepted 2 August 2019 Correspondence to Jian Gong, MD, Department of Gastroenterology, The First Affiliated Hospital, Dalian Medical University, 222 Zhongshan Road, Dalian, Liaoning 116011, P.R. China, Tel: +0086 18098875393; fax:+0086 0411 83622844; e-mail: [email protected]

10.1097/meg.0000000000001557

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