Anthony Nonell

Université Paris-Saclay

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Francesco Sortino

Istituto Nazionale di Geofisica e Vulcanologia

Mireille Polvé

Géosciences Environnement Toulouse

Jean Toutain

Fondation Ophtalmologique Adolphe de Rothschild

Marguerite Munoz

Géosciences Environnement Toulouse

Sri Sumarti

Badan Pengkajian dan Penerapan Teknologi

Jean‐Paul Toutain

Observatoire Midi-Pyrénées

Jeroen E. Sonke

Centre National de la Recherche Scientifique

Pascal E. Reiller

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Bernard Dupré

University of North Dakota

Patrick Richon

CEA DAM Île-de-France

Cooperative Institutions

Centre National de la Recherche Scientifique

Université Toulouse III - Paul Sabatier

Observatoire Midi-Pyrénées

Institut de Recherche pour le Développement

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

CEA Paris-Saclay

Université de Toulouse

Université Paris-Saclay

Géosciences Environnement Toulouse

Direction des énergies

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Evidence for Zn isotopic variations at Merapi active volcanic system

HAL (Le Centre pour la Communication Scientifique Directe) (2008)

Jean Toutain Jeroen E. Sonke Mauricio Muñoz Anthony Nonell Mireille Polvé

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Impact of uranium uptake on isotopic fractionation and endogenous element homeostasis in human neuron-like cells

Scientific Reports (2018)

Eduardo Paredes Émilie Avazeri Véronique Malard Claude Vidaud Pascal E. Reiller

The impact of natural uranium (U) on differentiated human neuron-like cells exposed to 1, 10, 125, and 250 µM of U for seven days was assessed. In particular, the effect of the U uptake on the homeostatic modulation of several endogenous elements (Mg, P, Mn, Fe, Zn, and Cu), the U isotopic fractionation upon its incorporation by the cells and the evolution of the intracellular Cu and Zn isotopic signatures were studied. The intracellular accumulation of U was accompanied by a preferential uptake of 235U for cells exposed to 1 and 10 µM of U, whereas no significant isotopic fractionation was observed between the extra- and the intracellular media for higher exposure U concentrations. The U uptake was also found to modulate the homeostasis of Cu, Fe, and Mn for cells exposed to 125 and 250 µM of U, but the intracellular Cu isotopic signature was not modified. The intracellular Zn isotopic signature was not modified either. The activation of the non-specific U uptake pathway might be related to this homeostatic modulation. All together, these results show that isotopic and quantitative analyses of toxic and endogenous elements are powerful tools to help deciphering the toxicity mechanisms of heavy metals.

Homeostasis

10.1038/s41598-018-35413-4

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Citations (13)

A new collector for sampling volcanic aerosols

Journal of Volcanology and Geothermal Research (2003)

Jean Toutain Francesco Sortino B Reynier Bernard Dupré Marguerite Munoz

10.1016/s0377-0273(03)00030-1

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Evidence of Zn isotopic fractionation in a soil–plant system of a pristine tropical watershed (Nsimi, Cameroon)

Chemical Geology (2007)

Jérôme Viers Priscia Oliva Anthony Nonell Alexandre Gélabert Jeroen E. Sonke

Saprolite

Soil horizon

Parent rock

Plant litter

10.1016/j.chemgeo.2007.01.005

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Citations (202)

Soil gas mapping and Rn emanation as indicators of lowering permeabilities at Merapi volcano

EAEJA (2003)

Jean Toutain Francesco Sortino Patrick Richon Anthony Nonell Antonius Ratdomopurbo

Lahar

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First coupled Sr and Pb isotopic measurements in volcanic gas condensates and groundwaters of Vulcano Island (Italy)

Geochemistry Geophysics Geosystems (2005)

Anthony Nonell Jean‐Paul Toutain Mireille Polvé Marguerite Munoz Gilles Berger

For the first time, coupled Sr‐Pb concentrations and isotopic compositions have been measured on four crater fumaroles and six groundwaters sampled between 1999 and 2001 at Vulcano Island, southern Italy. Sr concentrations and isotopic compositions of groundwaters show that the Sr budget results mainly from the leaching of volcanic rock by groundwaters. Leaching intensity is controlled by the variable dissolution of volcanic gases into shallow aquifers. The data do not reveal any influence of seawater except at one coastal site. Low Pb concentrations together with calculated saturation indexes with respect to mineral phases indicate that Pb content in groundwaters is strongly influenced by adsorption and/or precipitation processes. Pb isotopic ratios of two steam‐heated waters display a clear anthropized meteoric water signature, suggesting gas dissolution or wall rock alteration to be a negligible process for this element in this particular context. Low (≈0.5) and high (10 2 –10 3 ) enrichment factors were calculated for Sr and Pb, respectively, indicating their refractory and volatile behavior in volcanic gases. Most of the gas samples display Sr and Pb isotopic ratios similar to parent rocks. These data suggest that Sr is mainly derived from wall rock or particle contamination during gas ascent, whereas Pb results mainly from magma degassing. However, two gas condensates collected from two different fumarolic vents and at different periods show a dramatic Pb and Sr isotopic shift with a clear atmospheric/anthropogenic signature. Episodic permeability variations of the volcanic structure, probably arising from microseismicity swarms, changes of local stress field, and migration of self‐sealing processes lead to changing interactions between freshly infiltrated meteoric water and volcanic gases that temporarily modify the trace metal signature of the fumarolic gas.

Fumarole

Isotopic signature

Volcanic Gases

Crater lake

10.1029/2005gc000980

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Citations (13)

A new method for sampling fumarolic gases: Analysis of major, minor and metallic trace elements with ammonia solutions

Journal of Volcanology and Geothermal Research (2006)

Francesco Sortino Anthony Nonell Jean Toutain M. Muñoz M. Valladon

10.1016/j.jvolgeores.2006.05.005

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Citations (26)

First strontium and lead isotopic measurements in volcanic gases : constraints on the hydrovolcanic system of Vulcano island (Italy).

EAEJA (2003)

Anthony Nonell Jean Toutain Mauricio Muñoz Mireille Polvé

Lead (geology)

Volcanic Gases

Isotopes of strontium

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Evidence for Zn isotopic fractionation at Merapi volcano

Chemical Geology (2008)

Jean‐Paul Toutain Jeroen E. Sonke Marguerite Munoz Anthony Nonell Mireille Polvé

Isotopic signature

10.1016/j.chemgeo.2008.04.007

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Citations (86)

Evidence of isotopic fractionation of natural uranium in cultured human cells

Proceedings of the National Academy of Sciences (2016)

Eduardo Paredes Émilie Avazeri Véronique Malard Claude Vidaud Pascal E. Reiller

Significance In vivo isotopic fractionation studies of metals in living organisms have recently revealed an outstanding potential for biomedical and toxicological studies. In vitro studies in cellular models are underexploited, although they have the potential to provide invaluable information to understand the processes at the origin of such isotopic fractionations. This work demonstrates the isotopic fractionation of natural uranium during its uptake by neuron-like human cells. The direction of isotopic fractionation provided clues for the identification of potential U incorporation pathways into cells, unknown until now. These findings open new perspectives on the use of isotopic fractionation of metals in cellular models for the investigation of metabolic processes, the identification of new biomarkers, and the interpretation of clinical results.

Mass-independent fractionation

Equilibrium fractionation

Depleted Uranium

10.1073/pnas.1610885113

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Citations (24)