Gary L. Westbrook

Vollum Institute

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Heidi Owen

Oregon Health & Science University

Eric Gouaux

Oregon Health & Science University

Farzad Jalali‐Yazdi

Oregon Health & Science University

Janette Myers

Oregon Health & Science University

John D. Clements

Tulane University

Mark L. Mayer

National Institutes of Health

Craig E. Jahr

Vollum Institute

Christian Rosenmund

Charité - Universitätsmedizin Berlin

Robin A. J. Lester

University of Alabama at Birmingham

Bryan W. Luikart

Dartmouth College

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Oregon Health & Science University

Vollum Institute

National Institutes of Health

Howard Hughes Medical Institute

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Columbia University

University of California, San Diego

Baylor College of Medicine

The University of Texas Southwestern Medical Center

University of California, San Francisco

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Data for EMSL Project 51316 from August 2021

OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2021)

Eric Gouaux Janette Myers Farzad Jalali‐Yazdi Heidi Owen Gary L. Westbrook

10.25582/data.2021-08.2308349/1931233

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Citations (0)

Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons

Nature (1994)

Christian Rosenmund Daniel W. Carr Susan E. Bergeson Gajanan Nilaver John D. Scott

Kainate receptor

10.1038/368853a0

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Citations (373)

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

Proceedings of the National Academy of Sciences (2010)

Stephen T. Magill Xiaolu A. Cambronne Bryan W. Luikart Daniel T. Lioy Barbara H. Leighton

Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and their integration into the dentate network. Among its many targets, the transcription factor CREB activates expression of a gene locus that produces two microRNAs, miR-132 and miR-212. In cultured cortical and hippocampal neurons, miR-132 functions downstream from CREB to mediate activity-dependent dendritic growth and spine formation in response to a variety of signaling pathways. To investigate whether miR-132 and/or miR-212 contribute to the maturation of dendrites in newborn neurons in the adult hippocampus, we inserted LoxP sites surrounding the miR-212/132 locus and specifically targeted its deletion by stereotactically injecting a retrovirus expressing Cre recombinase. Deletion of the miR-212/132 locus caused a dramatic decrease in dendrite length, arborization, and spine density. The miR-212/132 locus may express up to four distinct microRNAs, miR-132 and -212 and their reverse strands miR-132* and -212*. Using ratiometric microRNA sensors, we determined that miR-132 is the predominantly active product in hippocampal neurons. We conclude that miR-132 is required for normal dendrite maturation in newborn neurons in the adult hippocampus and suggest that this microRNA also may participate in other examples of CREB-mediated signaling.

10.1073/pnas.1015691107

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Citations (413)

Nonuniform Probability of Glutamate Release at a Hippocampal Synapse

Science (1993)

Christian Rosenmund John D. Clements Gary L. Westbrook

A change in the probability of neurotransmitter release ( P r ) is an important mechanism underlying synaptic plasticity. Although P r is often assumed to be the same for all terminals at a single synapse, this assumption is difficult to reconcile with the nonuniform size and structure of synaptic terminals in the central nervous system. Release probability was measured at excitatory synapses on cultured hippocampal neurons by analysis of the progressive block of N -methyl-D-aspartate receptor-mediated synaptic currents by the irreversible open channel blocker MK-801. Release probability was nonuniform (range of 0.09 to 0.54) for terminals arising from a single axon, the majority of which had a low P r . However, terminals with high P r are more likely to be affected by the activity-dependent modulation that occurs in long-term potentiation.

Excitatory synapse

Silent synapse

10.1126/science.7901909

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Citations (643)

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

Nature (1984)

Mark L. Mayer Gary L. Westbrook Peter B. Guthrie

Aspartic acid

10.1038/309261a0

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Citations (2,835)