Zhaoyan Wang

Shanghai Ninth People's Hospital

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Xiaoming Zhang

Shenzhen Bao'an District People's Hospital

Xiaolin Yin

China Institute of Water Resources and Hydropower Research

Xiang Liu

Anhui University of Science and Technology

Chunhong Hu

China Institute of Water Resources and Hydropower Research

Wenhong Cao

Guangdong Ocean University

Yousheng Wang

Beijing Technology and Business University

Gang Xie

Shandong Academy of Environmental Science

Bing Liu

Northwest Institute of Eco-Environment and Resources

Hao Wu

Shanghai Ninth People's Hospital

Yang Zhao

Chengdu University of Technology

Cooperative Institutions

Shanghai Jiao Tong University

Shanghai Ninth People's Hospital

Chinese Academy of Sciences

China Institute of Water Resources and Hydropower Research

Beijing Forestry University

Tsinghua University

Tianjin University

State Forestry and Grassland Administration

Peking University

XinHua Hospital

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Differential NF2 Gene Status in Sporadic Vestibular Schwannomas and its Prognostic Impact on Tumour Growth Patterns

Scientific Reports (2017)

Hongsai Chen Lu Xue Hantao Wang Zhaoyan Wang Hao Wu

The great majority of sporadic vestibular schwannomas (VSs) are due to the inactivation of the NF2 gene. In this study, we found age-dependent differences in the clinical parameters of sporadic VSs. Young patients were characterized by progressive tumour behaviours, including earlier onset of initial symptoms, shorter symptom duration and larger tumour size. An increased rate of "two-hits" of both NF2 alleles, usually by mutation and allelic loss, was observed in young cases compared to older, and this correlated with the loss of protein and mRNA expression. In contrast, the tumours with a single mutation (referred to as 'one-hit') exhibited obvious expression levels. Moreover, a mixture of merlin-expressing tumour cells and non-expressing tumour cells was observed in 'one-hit' schwannomas, suggesting that a subset of 'one-hit' tumour cells was present in these tumours. To mimic the growth promoting effects by the second hit, we performed lentivirus-mediated NF2 knockdown in the 'one-hit' schwannoma cultures. Following the loss of NF2 expression, schwannoma cultures demonstrated increased proliferation rates. Above all, we have identified a correlation between the NF2 status and the growth patterns of sporadic VSs. The treatment decision-making, microsurgery or "wait and scan" strategy, should be carried out according to the tumour's genetic background.

Merlin (protein)

Vestibular Schwannomas

10.1038/s41598-017-05769-0

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Citations (30)

Targeted Next-Generation Sequencing in Uyghur Families with Non-Syndromic Sensorineural Hearing Loss

PLoS ONE (2015)

Ying Chen Zhentao Wang Zhaoyan Wang Dongye Chen Yongchuan Chai

The mutation spectrum of deafness genes may vary in different ethnical groups. In this study, we investigated the genetic etiology of nonsyndromic deafness in four consanguineous and two multiplex Uyghur families in which mutations in common deafness genes GJB2, SLC26A4 and MT-RNR1 were excluded. Targeted next-generation sequencing of 97 deafness genes was performed in the probands of each family. Novel pathogenic mutations were identified in four probands including the p.L416R/p.A438T compound heterozygous mutations in TMC1, the homozygous p.V1880E mutation in MYO7A, c.1238delT frameshifting deletion in PCDH15 and c.9690+1G>A splice site mutation in MYO15A. Co-segregation of the mutations and the deafness were confirmed within each family by Sanger sequencing. No pathogenic mutations were identified in one multiplex family and one consanguineous family. Our study provided a useful piece of information for the genetic etiology of deafness in Uyghurs.

Proband

Sanger sequencing

Compound heterozygosity

10.1371/journal.pone.0127879

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Citations (28)

Leader-Following Regional Multiple-Bipartite Consensus for Networked Lagrangian Systems with Coopetition Interactions

Symmetry (2021)

Tiehui Zhang Hengyu Li Zhaoyan Wang Shaorong Xie

This paper investigates the leader-following regional multiple-bipartite consensus problems of networked Lagrangian systems (NLSs) in coopetition networks. Our framework expands the application scopes of traditional regional consensus in cooperative networks. With the aid of a novel auxiliary variable embedded in the control protocols, the final states of NLSs are guaranteed to realise multi-regional symmetry in the constructed multiple symmetric regions. By utilising the characteristic of acyclic topology in the structurally balanced graph, the stability of the closed system is performed by perturbation analysis theory, nonlinear control theory, functional analysis theory, and so on. Finally, the effectiveness of our approach is verified by numerical simulations.

Coopetition

Decentralised system

10.3390/sym13060920

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Citations (1)

Coadsorption of Cu(II) and tylosin/sulfamethoxazole on biochar stabilized by nano-hydroxyapatite in aqueous environment

Chemical Engineering Journal (2019)

Zhen Li Miao Li Zhaoyan Wang Xiang Liu

Tylosin

Sulfamethoxazole

10.1016/j.cej.2019.122785

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Citations (71)

Scaling Up from Leaf to Whole-Plant Level for Water Use Efficiency Estimates Based on Stomatal and Mesophyll Behaviour in Platycladus orientalis

Water (2022)

Yonge Zhang Bing Liu Guodong Jia Xinxiao Yu Xiaoming Zhang

Prediction of whole-plant short-term water use efficiency (WUEs,P) is essential to indicate plant performance and facilitate comparison across different temporal and spatial scales. In this study, an isotope model was scaled up from the leaf to the whole-plant level, in order to simulate the variation in WUEs,P in response to different CO2 concentrations (Ca; 400, 600, and 800 μmol·mol−1) and soil water content (SWC; 35–100% of field capacity). For WUEs,P modelling, leaf gas exchange information, plant respiration, and “unproductive” water loss were taken into account. Specifically, in shaping the expression of the WUEs,P, we emphasized the role of both stomatal (gsw) and mesophyll conductance (gm). Simulations were compared with the measured results to check the model’s applicability. The verification showed that estimates of gsw from the coupled photosynthesis (Pn,L)-gsw model accounting for the effect of soil water stress slightly outperformed the model neglecting the soil water status effect. The established coupled Pn,L-gm model also proved more effective in estimating gm than the previously proposed model. Introducing the two diffusion control functions into the whole-plant model, the developed model for WUEs,P effectively captured its response pattern to different Ca and SWC conditions. Overall, this study confirmed that the accurate estimation of WUEs,P requires an improved predictive accuracy of gsw and gm. These results have important implications for predicting how plants respond to climate change.

Platycladus

Stomatal Conductance

10.3390/w14020263

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Citations (3)

Response of sediment discharge to soil erosion control in the middle reaches of the Yellow River

CATENA (2021)

Yang Zhao Chunhong Hu Xiaoming Zhang Xizhi Lv Xiaolin Yin

Water discharge

Discharge

10.1016/j.catena.2021.105330

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Citations (28)

Dependence of the sediment delivery ratio on scale and its fractal characteristics

International Journal of Sediment Research (2015)

Xiaoming Zhang Sihong Wu Wenhong Cao Jianchao Guan Zhaoyan Wang

10.1016/j.ijsrc.2015.03.011

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Citations (15)

Analysis of changes in characteristics of flood and sediment yield in typical basins of the Yellow River under extreme rainfall events

CATENA (2019)

Yang Zhao Wenhong Cao Chunhong Hu Yousheng Wang Zhaoyan Wang

10.1016/j.catena.2019.02.001

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Citations (70)

Application of 137Cs tracer technique in floodplain deposition research in mesoscale river basins

Geoderma (2023)

Bing Liu Zhaoyan Wang Xiaoming Zhang Gang Xie Bing Yin

Floodplain deposition can provide important historical information about river systems. 137Cs tracer measurement is the most widely used technique for studying floodplain deposition. One-time sampling is normally used to date or estimate erosion and deposition rates, while time-interval sampling has rarely been applied. Northeast China is an important grain production area characterized by intense erosion and a low sediment transport ratio. Most studies of the region have focused on slope sedimentation, while floodplain sedimentation has received little attention. In this study, two-time steps of cross-sectional sediment core sample collection were performed to examine the floodplain sedimentation in the river basin of the Laolai River, a tributary of the Songhua River. The potential for using 137Cs to estimate the sediment deposition rate for a given time-interval was also investigated. A total of 18 cross-sections were acquired, and three repeated cross-sections were selected for double sampling. Significant differences were observed between the results obtained from the samples collected in separate rounds, suggesting the presence of internal heterogeneity during floodplain sedimentation and a significant influence of sampling positions on the analysis results. In the basin examined, sedimentation often occurs midstream, upstream, and at the outlet, and was mainly affected by topography, reservoir construction, and land use. Sedimentation occurs easily at wide, flat outlets or river intersections in braided water systems. It was observed that downstream floodplain sedimentation was increased by sediment interception by upstream reservoirs, but reduced by forests near floodplains. Sedimentation rates were significantly different between the 1954 and 1963 time markers, and we found that using rates from 1954 alone would lead to underestimation. When 137Cs sedimentation and floodplain distribution are used to determine flooding occurrence, variations in 137Cs content and particle size distribution should be considered. River bank erosion in this region should be taken into account, and riparian protection is required to reduce erosion and floodplain deposition. Since 137Cs is absent in fine particles when the sediment is predominantly sand, 137Cs measurement may underestimate the sediment deposition rate.

Sedimentation

Deposition

TRACER

10.1016/j.geoderma.2023.116706

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Citations (0)

Association of fruit and vegetables with the risk of nasopharyngeal cancer: Evidence from a meta-analysis

Scientific Reports (2014)

Jian Jin Zhiguo Ouyang Zhaoyan Wang

Quantification of the association between the intake of vegetables and fruit and risk of nasopharyngeal cancer (NPC) is controversial. Thus, we conducted a meta-analysis to assess the relationship between vegetables and fruit and NPC risk. Pertinent studies were identified by a search in PubMed, Web of Knowledge and Wan Fang Med Online. Random-effects models were used to calculate summary relative risks (RRs) and the corresponding 95% confidence intervals (CIs). Publication bias was estimated using Egger's regression asymmetry test. Finally, 15 articles comprising 8208 NPC cases were included in this meta-analysis. The combined results showed that there was significant association between vegetables and fruit intake and NPC risk. The pooled RRs were 0.60 (95% CI = 0.47–0.76) for vegetables and 0.63 (95% CI = 0.56–0.70) for fruit. No publication bias was detected. Our analysis indicated that intake of vegetables and fruit may have a protective effect on NPC. Since the potential biases and confounders could not be ruled out completely in this meta-analysis, further studies are needed.

Nasopharyngeal cancer

Fruit juice

10.1038/srep05229

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Citations (16)