In this paper,we give a review on combined ESR/U-series methods for dating tooth fossil from Middle-Early Pleistocene sites.This approach allows estimating the history of uranium uptake in each dental tissue by using a one-parameter(p-value) diffusion equation,being more accurate than the conventional methods where the mode of uranium uptake is predetermined.Conventional ESR dating postulates two models: an early uptake(EU) model which assumes that uranium was incorporated shortly after the sample burial,and a linear uptake(LU) model where uranium is supposed to have been incorporated at a constant rate since the time of burial.The previous works stated that correct ESR age of a sample lies always somewhere between the EU and LU uptake ages.In recent years,combined ESR/U-series methods are becoming known as a unique approach for dating old fossils directly,and were applied on several archaeological sites in the world.The archaeologists and dating specialists in China are called on to make a good joint effort and collaboration in installing and developing the combined ESR/U-series dating methods and to carry out better studies on chronology of Middle-Early Pleistocene sites.